Silent somatotropinomas.
Minerva Endocrinol
; 44(2): 137-142, 2019 Jun.
Article
in En
| MEDLINE
| ID: mdl-30531696
Silent somatotroph pituitary neuroendocrine tumors (or silent growth hormone pituitary neuroendocrine tumors, SGH-PitNET) are neoplasias with positive immunostaining for growth hormone (GH), in patients with no signs and symptoms of acromegaly nor biochemical evidence of GH hypersecretion. From a clinical stand-point they are considered and managed as non-functioning pituitary tumors, since they usually come to evidence due to mass-effects (headache, visual impairment, hypopituitarism) or as asymptomatic pituitary incidentalomas. SGH-PitNET have deserved little attention in the medical literature, and no specific guidelines exist regarding their management. However, identification of a particular tumor lineage through immunostaining patterns of non-functioning pituitary tumors may determine postoperative medical therapy in the near future. This review updates the current knowledge about the epidemiologic, clinical, pathological and molecular characteristics of this particular type of pituitary tumors.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adenoma
/
Growth Hormone-Secreting Pituitary Adenoma
Type of study:
Guideline
/
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Minerva Endocrinol
Year:
2019
Document type:
Article
Country of publication: