Plasma circulating tumor DNA as a potential tool for disease monitoring in head and neck cancer.
Head Neck
; 41(5): 1351-1358, 2019 05.
Article
in En
| MEDLINE
| ID: mdl-30554450
ABSTRACT
BACKGROUND:
Recommendations for perioperative therapy in head and neck cancer are not explicit and recurrence occurs frequently. Circulating tumor DNA is an emerging cancer biomarker, but has not been extensively explored for detection of recurrence in head and neck cancer.METHODS:
Patients diagnosed with head and neck squamous cell carcinoma were recruited into the study protocol. Tumors were sequenced to identify patient-specific mutations. Mutations were then identified in plasma circulating tumor DNA from pre-treatment blood samples and longitudinally during standard follow-up. Circulating tumor DNA status during follow-up was correlated to disease recurrence.RESULTS:
Samples were taken from eight patients. Tumor mutations were verified in seven patients. Baseline circulating tumor DNA was positive in six patients. Recurrence occurred in four patients, two of whom had detectable circulating tumor DNA prior to recurrence.CONCLUSION:
Circulating tumor DNA is a potential tool for disease and recurrence monitoring following curative therapy in head and neck cancer, allowing for better prognostication, and/or modification of treatment strategies.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biomarkers, Tumor
/
Circulating Tumor DNA
/
Squamous Cell Carcinoma of Head and Neck
/
Head and Neck Neoplasms
/
Neoplasm Recurrence, Local
Type of study:
Etiology_studies
/
Guideline
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
America do norte
Language:
En
Journal:
Head Neck
Journal subject:
NEOPLASIAS
Year:
2019
Document type:
Article
Affiliation country: