Your browser doesn't support javascript.
loading
CSF TACI and BAFF levels in patients with primary CNS lymphoma as novel diagnostic biomarkers.
Mizutani, Hironori; Nakane, Shunya; Ikeda, Tokunori; Nakamura, Hideo; Takamatsu, Koutaro; Makino, Keishi; Tawara, Nozomu; Mukaino, Akihiro; Watari, Mari; Matsui, Hirotaka; Mukasa, Akitake; Ando, Yukio.
Affiliation
  • Mizutani H; Department of Neurology Graduate School of Medical Sciences Kumamoto University Kumamoto Japan.
  • Nakane S; Department of Neurology Graduate School of Medical Sciences Kumamoto University Kumamoto Japan.
  • Ikeda T; Department of Molecular Neurology and Therapeutics Kumamoto University Hospital Kumamoto Japan.
  • Nakamura H; Department of Neurology Graduate School of Medical Sciences Kumamoto University Kumamoto Japan.
  • Takamatsu K; Department of Clinical Investigation (Biostatistics) Kumamoto University Hospital Kumamoto Japan.
  • Makino K; Department of Neurosurgery Graduate School of Medical Sciences Kumamoto University Kumamoto Japan.
  • Tawara N; Department of Neurology Graduate School of Medical Sciences Kumamoto University Kumamoto Japan.
  • Mukaino A; Department of Neurosurgery Graduate School of Medical Sciences Kumamoto University Kumamoto Japan.
  • Watari M; Department of Neurology Graduate School of Medical Sciences Kumamoto University Kumamoto Japan.
  • Matsui H; Department of Molecular Neurology and Therapeutics Kumamoto University Hospital Kumamoto Japan.
  • Mukasa A; Department of Neurology Graduate School of Medical Sciences Kumamoto University Kumamoto Japan.
  • Ando Y; Department of Molecular Neurology and Therapeutics Kumamoto University Hospital Kumamoto Japan.
Ann Clin Transl Neurol ; 5(12): 1611-1616, 2018 Dec.
Article in En | MEDLINE | ID: mdl-30564626
ABSTRACT
We used an enzyme-linked immunosorbent assay to measure pretreatment B cell-activating factor belonging to the tumour necrosis factor family (BAFF) and transmembrane activator and CAML-interactor (TACI) levels in CSF and serum collected from patients with primary central nervous system lymphoma (PCNSL) and control groups. The decision tree analysis of CSF TACI and BAFF levels for patients with a PCNSL diagnosis showed 100% sensitivity and 100% specificity when we attempted to differentiate PCNSL from glioblastoma and CNS inflammatory diseases. The combination of CSF TACI and BAFF levels may thus be a novel and useful diagnostic biomarker of PCNSL.
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: Ann Clin Transl Neurol Year: 2018 Document type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: Ann Clin Transl Neurol Year: 2018 Document type: Article