Effects of maternal bisphenol A on behavior, sex steroid and thyroid hormones levels in the adult rat offspring.
Life Sci
; 218: 253-264, 2019 Feb 01.
Article
in En
| MEDLINE
| ID: mdl-30586564
ABSTRACT
AIMS:
Bisphenol A (BPA), an endocrine disruptor used in industrial applications, has been detected in both placenta and milk. We studied the effects of BPA exposure during pregnancy and lactation on body composition, palatable food intake, biochemical, hormonal and behavioral profiles of young and adult Wistar rat offspring. MAINMETHODS:
Female rats were divided into control, BPA10 (10⯵g/kg/day) and BPA50 (50⯵g/kg/day). BPA was administered by gavage to dams from gestation until the end of lactation. Euthanasia occurred at weaning [postnatal day (PN) 21] or adulthood (PN180). KEYFINDINGS:
At weaning, BPA10 female pups had higher plasma cholesterol and triacylglycerol. BPA10 male pups showed lower plasma T3. BPA10 pups of both sexes had higher plasma progesterone, testosterone and estradiol. At adulthood, females of both BPA groups had lower food intake and higher insulinemia, whereas males had lower visceral fat, lower progesterone and testosterone concentrations. BPA10 females and males had lower T4 levels, while only males showed lower estradiol. BPA50 females showed lower fat mass, higher lean mass and lower corticosteronemia, while males had lower food intake. In the feeding study, BPA10 males ate more fat at 30â¯min, while BPA10 females and males ingested less fat after 12â¯h. BPA10 females showed hyperactivity while both groups showed less exploration.SIGNIFICANCE:
Maternal exposure to BPA during gestation and lactation, even at low doses, induces life-long changes in the regulation of metabolic homeostasis of the progeny, affects sex steroids and thyroid hormones levels, compromises behavior, but does not lead to obesity or dyslipidemia.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenols
/
Sexual Behavior
/
Gonadal Steroid Hormones
/
Thyroid Hormones
/
Benzhydryl Compounds
/
Maternal Exposure
Limits:
Animals
Language:
En
Journal:
Life Sci
Year:
2019
Document type:
Article
Affiliation country: