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Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.
Lai, Yen-Ting; Wang, Tao; O'Dell, Sijy; Louder, Mark K; Schön, Arne; Cheung, Crystal S F; Chuang, Gwo-Yu; Druz, Aliaksandr; Lin, Bob; McKee, Krisha; Peng, Dongjun; Yang, Yongping; Zhang, Baoshan; Herschhorn, Alon; Sodroski, Joseph; Bailer, Robert T; Doria-Rose, Nicole A; Mascola, John R; Langley, David R; Kwong, Peter D.
Affiliation
  • Lai YT; Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Wang T; Departments of Discovery Chemistry and Molecular Technologies, Bristol-Myers Squibb Research and Development, Cambridge, MA, 02142, USA.
  • O'Dell S; Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Louder MK; Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Schön A; Department of Biology, Johns Hopkins University, Baltimore, MD, 21218, USA.
  • Cheung CSF; Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Chuang GY; Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Druz A; Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Lin B; Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, 20892, USA.
  • McKee K; Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Peng D; Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Yang Y; Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Zhang B; Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Herschhorn A; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA.
  • Sodroski J; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, 55455, USA.
  • Bailer RT; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA.
  • Doria-Rose NA; Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Mascola JR; Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Langley DR; Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Kwong PD; Computer Assisted Drug Design, Bristol-Myers Squibb Research and Development, Wallingford, CT, 06492, USA.
Nat Commun ; 10(1): 47, 2019 01 03.
Article in En | MEDLINE | ID: mdl-30604750
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Envelope Protein gp120 / Chemical Engineering / HIV-1 / HIV Fusion Inhibitors / Virus Internalization Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Envelope Protein gp120 / Chemical Engineering / HIV-1 / HIV Fusion Inhibitors / Virus Internalization Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Document type: Article Affiliation country: Country of publication: