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Circulating Microparticles in Children With Sickle Cell Anemia in a Tertiary Center in Upper Egypt.
Zahran, Asmaa M; Elsayh, Khalid I; Saad, Khaled; Embaby, Mostafa M; Youssef, Mervat A M; Abdel-Raheem, Yasser F; Sror, Shaban M; Galal, Shereen M; Hetta, Helal F; Aboul-Khair, Mohamed Diab; Alblihed, Mohamd A; Elhoufey, Amira.
Affiliation
  • Zahran AM; 1 Department of Clinical Pathology, South Egypt Cancer Institute, Assiut, Egypt.
  • Elsayh KI; 2 Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Saad K; 2 Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Embaby MM; 2 Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Youssef MAM; 2 Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Abdel-Raheem YF; 2 Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Sror SM; 2 Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Galal SM; 2 Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Hetta HF; 3 Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Aboul-Khair MD; 4 Department of Pediatrics, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
  • Alblihed MA; 5 Department of Medical Biochemistry, School of Medicine Taif University Taif Saudi Arabia, Taif, Saudi Arabia.
  • Elhoufey A; 6 Department of Community Health Nursing, Faculty of Nursing, Assiut University, Assiut, Egypt.
Clin Appl Thromb Hemost ; 25: 1076029619828839, 2019.
Article in En | MEDLINE | ID: mdl-30740989
Sickle cell disease (SCD) is a genetically inherited hemolytic anemia increasingly appreciated as a chronic inflammatory condition and hypercoagulable state with high thrombotic risk. It is associated with disturbed immune phenotype and function and circulating microparticles (MPs) derived from multiple cell sources. This study was carried out to determine MPs profiles in patients with sickle cell anemia (either on hydroxyurea (HU) therapy or those with no disease-modifying therapy) and to compare these profiles with healthy children. Moreover, our study assesses the potential impact of HU on other aspects of circulating MPs. We performed a cross-sectional study on 30 pediatric patients with SCD divided by treatment into 2 groups (those receiving HU or no therapy) attending Hematology Clinic and 20 age-matched healthy children. The blood samples obtained were analyzed for MPs by flow cytometry. Sickle cell disease group with no therapy showed elevated levels of total, platelet, and erythroid MPs. In contrast, therapy with HU was associated with normalization of MPs. This study provided additional evidence that HU is an effective treatment option in pediatric patients with SCD, as it seems that it decreases the abnormally elevated MPs in those patients.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell-Derived Microparticles / Anemia, Sickle Cell Type of study: Observational_studies / Risk_factors_studies Limits: Child / Female / Humans / Male Country/Region as subject: Africa Language: En Journal: Clin Appl Thromb Hemost Journal subject: ANGIOLOGIA Year: 2019 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell-Derived Microparticles / Anemia, Sickle Cell Type of study: Observational_studies / Risk_factors_studies Limits: Child / Female / Humans / Male Country/Region as subject: Africa Language: En Journal: Clin Appl Thromb Hemost Journal subject: ANGIOLOGIA Year: 2019 Document type: Article Affiliation country: Country of publication: