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Autoantibody detection is not recommended for chronic pancreatitis: a cross-sectional Study of 557 patients.
Zeng, Xiang-Peng; Liu, Ting-Ting; Hao, Lu; Xin, Lei; Wang, Teng; He, Lin; Pan, Jun; Wang, Dan; Bi, Ya-Wei; Ji, Jun-Tao; Liao, Zhuan; Du, Ting-Ting; Lin, Jin-Huan; Zhang, Di; Guo, Hong-Lei; Chen, Hui; Zou, Wen-Bin; Li, Bai-Rong; Cong, Zhi-Jie; Wang, Li-Sheng; Xu, Zheng-Lei; Xie, Ting; Liu, Ming-Hao; Deng, An-Mei; Li, Zhao-Shen; Hu, Liang-Hao.
Affiliation
  • Zeng XP; Department of Gastroenterology, Gongli Hospital, The Second Military Medical University, Shanghai, China.
  • Liu TT; Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Hao L; Department of Laboratory Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Xin L; Department of Gastroenterology, Hainan Branch of Chinese PLA General Hospital, Sanya, China.
  • Wang T; Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • He L; Department of Gastroenterology, Gongli Hospital, The Second Military Medical University, Shanghai, China.
  • Pan J; Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Wang D; Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Bi YW; Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Ji JT; Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Liao Z; Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Du TT; Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Lin JH; Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Zhang D; Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Guo HL; Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Chen H; Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Zou WB; Department of Gastroenterology, Gongli Hospital, The Second Military Medical University, Shanghai, China.
  • Li BR; Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Cong ZJ; Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Wang LS; Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Xu ZL; Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Xie T; Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Liu MH; Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Deng AM; Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Li ZS; Department of Gastroenterology, Gongli Hospital, The Second Military Medical University, Shanghai, China.
  • Hu LH; Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
BMC Gastroenterol ; 19(1): 31, 2019 Feb 14.
Article in En | MEDLINE | ID: mdl-30764766
ABSTRACT

BACKGROUND:

Autoimmune factor was regarded as one of the risk factors in the pathogenesis of chronic pancreatitis (CP), especially for autoimmune pancreatitis (AIP). However, whether autoimmune factor plays a role in non-AIP CP or not was unknown.

METHODS:

Hospitalized patients with non-AIP CP from January 2010 to October 2016 were detected for 22 autoantibodies at the time of hospital admission. Autoantibodies with frequency > 0.5% were enrolled to calculate the frequency in historial healthy controls through literature search in PubMed. Differentially expressed autoantibodies were determined between patients and historial healthy controls, and related factors were identified by multivariate logistic regression analysis.

RESULTS:

In a total of 557 patients, 113 cases were detected with 19 kinds of positive autoantibodies, among them anti-ß2-glycoprotein I (ß2-GPI) antibody was most frequent (9.16%). Compared with historial healthy controls, the frequencies of serum ß2-GPI and anti SS-B antibody in patients were significantly higher, while frequencies of anti-smooth muscle antibody and anticardiolipin antibody were significantly lower (all P < 0.05). Multivariate logistic regression analysis result showed that diabetes mellitus (OR = 2.515) and common bile duct stricture (OR = 2.844) were the risk factors of positive ß2-GPI antibody in patients while diabetes mellitus in first-/second-/third-degree relatives (OR = 0.266) was the protective factor. There were no related factors for other three differentially expressed autoantibodies.

CONCLUSIONS:

Four autoantibodies were expressed differentially between patients with non-AIP CP and historial healthy controls. Due to limited significance for diagnosis and treatment of chronic pancreatitis, autoantibodies detection is not recommended conventionally unless suspected of AIP.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoantibodies / Pancreatitis, Chronic Type of study: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Humans / Middle aged Language: En Journal: BMC Gastroenterol Journal subject: GASTROENTEROLOGIA Year: 2019 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoantibodies / Pancreatitis, Chronic Type of study: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Humans / Middle aged Language: En Journal: BMC Gastroenterol Journal subject: GASTROENTEROLOGIA Year: 2019 Document type: Article Affiliation country: