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Proton pump inhibitors promote the growth of androgen-sensitive prostate cancer cells through ErbB2, ERK1/2, PI3K/Akt, GSK-3ß signaling and inhibition of cellular prostatic acid phosphatase.
Gesmundo, Iacopo; Di Blasio, Laura; Banfi, Dana; Villanova, Tania; Fanciulli, Alessandro; Favaro, Enrica; Gamba, Giacomo; Musuraca, Chiara; Rapa, Ida; Volante, Marco; Munegato, Stefania; Papotti, Mauro; Gontero, Paolo; Primo, Luca; Ghigo, Ezio; Granata, Riccarda.
Affiliation
  • Gesmundo I; Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin and Città Della Salute e Della Scienza Hospital, Turin, 10126, Italy.
  • Di Blasio L; Candiolo Cancer Institute FPO-IRCCS, Candiolo, Turin, 10060, Italy; Department of Oncology, University of Turin, Turin, Italy.
  • Banfi D; Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin and Città Della Salute e Della Scienza Hospital, Turin, 10126, Italy.
  • Villanova T; Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin and Città Della Salute e Della Scienza Hospital, Turin, 10126, Italy.
  • Fanciulli A; Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin and Città Della Salute e Della Scienza Hospital, Turin, 10126, Italy.
  • Favaro E; Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin and Città Della Salute e Della Scienza Hospital, Turin, 10126, Italy.
  • Gamba G; Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin and Città Della Salute e Della Scienza Hospital, Turin, 10126, Italy.
  • Musuraca C; Department of Oncology, University of Turin, Turin, Italy; Città Della Salute e Della Scienza Hospital, Turin, 10126, Italy.
  • Rapa I; Department of Oncology, University of Turin, San Luigi Hospital, Orbassano, Turin, 10043, Italy.
  • Volante M; Department of Oncology, University of Turin, San Luigi Hospital, Orbassano, Turin, 10043, Italy.
  • Munegato S; Division of Urology, Department of Surgical Sciences, University of Turin and Città Della Salute e Della Scienza Hospital, Turin, 10126, Italy.
  • Papotti M; Department of Oncology, University of Turin, Turin, Italy; Città Della Salute e Della Scienza Hospital, Turin, 10126, Italy.
  • Gontero P; Division of Urology, Department of Surgical Sciences, University of Turin and Città Della Salute e Della Scienza Hospital, Turin, 10126, Italy.
  • Primo L; Candiolo Cancer Institute FPO-IRCCS, Candiolo, Turin, 10060, Italy; Department of Oncology, University of Turin, Turin, Italy.
  • Ghigo E; Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin and Città Della Salute e Della Scienza Hospital, Turin, 10126, Italy.
  • Granata R; Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin and Città Della Salute e Della Scienza Hospital, Turin, 10126, Italy. Electronic address: riccarda.granata@unito.it.
Cancer Lett ; 449: 252-262, 2019 05 01.
Article in En | MEDLINE | ID: mdl-30790678
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Acid Phosphatase / Omeprazole / Receptor, ErbB-2 / Mitogen-Activated Protein Kinase 1 / Mitogen-Activated Protein Kinase 3 / Cell Proliferation / Proto-Oncogene Proteins c-akt / Proton Pump Inhibitors / Phosphatidylinositol 3-Kinase Type of study: Diagnostic_studies Limits: Animals / Humans / Male Language: En Journal: Cancer Lett Year: 2019 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Acid Phosphatase / Omeprazole / Receptor, ErbB-2 / Mitogen-Activated Protein Kinase 1 / Mitogen-Activated Protein Kinase 3 / Cell Proliferation / Proto-Oncogene Proteins c-akt / Proton Pump Inhibitors / Phosphatidylinositol 3-Kinase Type of study: Diagnostic_studies Limits: Animals / Humans / Male Language: En Journal: Cancer Lett Year: 2019 Document type: Article Affiliation country: Country of publication: