Neurodegeneration, Heterochromatin, and Double-Stranded RNA.
J Exp Neurosci
; 13: 1179069519830697, 2019.
Article
in En
| MEDLINE
| ID: mdl-30792577
ABSTRACT
Changes in chromatin and epigenetic modifications have been associated with aging and aging-associated neurodegenerative diseases, although the causal relationship between these changes and disease-related pathology has been unclear. Recent studies have now made direct connections between neurodegeneration-associated proteins and derepression of repetitive element transcription due to changes in heterochromatin. We suggest that this derepression leads to an increased accumulation of intracellular double-stranded RNA (dsRNA), with an attendant induction of innate immune responses that contribute to the neuroinflammation found in essentially all age-associated neurodegenerative diseases.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Exp Neurosci
Year:
2019
Document type:
Article
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