Co-delivery of Cisplatin(IV) and Capecitabine as an Effective and Non-toxic Cancer Treatment.
Front Pharmacol
; 10: 110, 2019.
Article
in En
| MEDLINE
| ID: mdl-30837877
A strategy for preparing composite micelles (CM) containing both cisplatin(IV) [CisPt(IV)] prodrug and capecitabine using a co-assembly method is described in this study. The CM are capable of an effective release of the anticancer drug cisplatin(II) [CisPt(II)] and capecitabine via acid hydrolysis once they are internalized by cancer cells. Moreover, the CM display a synergistic effect in vitro and the combination therapy in the micellar dosage form leads to reduced systemic toxicity and enhanced antitumor efficacy in vivo.
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Front Pharmacol
Year:
2019
Document type:
Article
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