[Advances in microfluidic chip-based extracellular vesicle separation].
Se Pu
; 37(4): 343-347, 2019 Apr 08.
Article
in Zh
| MEDLINE
| ID: mdl-30977335
ABSTRACT
Extracellular vesicles (EVs) are hemispherical vesicles that have a lipid bilayer. Studies have shown that EVs have important biological functions. The amount, types, and compositional changes of proteins, lipids and ribonucleic acids are closely related to diseases. The separation and capture of EVs from the complicated body fluid samples is a prerequisite for medical research and liquid biopsy based on EVs. However, presently the majority of EVs separation and capture still use the traditional separation methods with low purity and low efficiency. Therefore, efficient and highly selective EVs separation method is in urgent need. To meet this challenge, advanced microfluidic chip technology, which has the advantages of miniaturization, integration, and automation, can be utilized. The development of EV separation technology combined with microfluidic chips has become the focus of research. This paper summarizes the latest research progress in this area.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Microfluidics
/
Extracellular Vesicles
Language:
Zh
Journal:
Se Pu
Year:
2019
Document type:
Article
Affiliation country: