miR-134 inhibits osteosarcoma cell invasion and metastasis through targeting MMP1 and MMP3 in vitro and in vivo.
FEBS Lett
; 593(10): 1089-1101, 2019 05.
Article
in En
| MEDLINE
| ID: mdl-30977909
ABSTRACT
miR-134 has been shown to be associated with angiogenesis and the progression of osteosarcoma. This study further assessed the effects of miR-134 expression on osteosarcoma cell migration, invasion, and metastasis in vitro and in a nude mouse xenograft model, exploring the underlying molecular events. Luciferase reporter assays revealed that miR-134 directly targets the 3'-UTRs of MMP1 and MMP3 to reduce their expression in osteosarcoma cells. In conclusion, overexpression of miR-134 suppresses osteosarcoma cell invasion and metastasis through the inhibition of MMP1 and MMP3 expression. We propose miR-134 as an attractive novel therapeutic target for the treatment of osteosarcoma.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bone Neoplasms
/
Osteosarcoma
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Gene Expression Regulation, Neoplastic
/
Matrix Metalloproteinase 3
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Matrix Metalloproteinase 1
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MicroRNAs
Limits:
Animals
/
Humans
Language:
En
Journal:
FEBS Lett
Year:
2019
Document type:
Article
Affiliation country: