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Kenalactams A-E, Polyene Macrolactams Isolated from Nocardiopsis CG3.
Messaoudi, Omar; Sudarman, Enge; Bendahou, Mourad; Jansen, Rolf; Stadler, Marc; Wink, Joachim.
Affiliation
  • Messaoudi O; Microbial Strain Collection , Helmholtz Centre for Infection Research GmbH (HZI) , Inhoffenstrasse 7 , 38124 Braunschweig , Germany.
  • Sudarman E; Laboratory of Applied Microbiology in Food and Environment , Abou bekr Belkaïd University , Tlemcen , Algeria.
  • Bendahou M; Department of Biology, Faculty of Science , University of Amar Telidji , Laghouat , Algeria.
  • Jansen R; Department Microbial Drugs , Helmholtz Centre for Infection Research GmbH (HZI) , Inhoffenstrasse 7 , 38124 Braunschweig , Germany.
  • Stadler M; German Centre for Infection Research Association (DZIF) , Partner site Hannover-Braunschweig, Inhoffenstrasse 7 , 38124 Braunschweig , Germany.
  • Wink J; Laboratory of Applied Microbiology in Food and Environment , Abou bekr Belkaïd University , Tlemcen , Algeria.
J Nat Prod ; 82(5): 1081-1088, 2019 05 24.
Article in En | MEDLINE | ID: mdl-31021629
In our screening program for new biologically active secondary metabolites, a new strain, Nocardiopsis CG3 (DSM 106572), isolated from the saltpan of Kenadsa, was found to produce five new polyene macrolactams, the kenalactams A-E (1-5). Their structures were elucidated by spectral methods (NMR and HRESIMS), and the absolute configuration was derived by chemical derivatization (Mosher's method). Through a feeding experiment, alanine was proven to be the nitrogen-bearing starter unit involved in biosynthesis of the polyketide kenalactam A (1). Kenalactam E (5) was cytotoxic against human prostate cancer PC-3 cells with an IC50 value of 2.1 µM.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyenes / Actinobacteria / Lactams Limits: Humans Language: En Journal: J Nat Prod Year: 2019 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyenes / Actinobacteria / Lactams Limits: Humans Language: En Journal: J Nat Prod Year: 2019 Document type: Article Affiliation country: Country of publication: