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Artificial Smooth Muscle Model Composed of Hierarchically Ordered Microtubule Asters Mediated by DNA Origami Nanostructures.
Matsuda, Kento; Kabir, Arif Md Rashedul; Akamatsu, Naohide; Saito, Ai; Ishikawa, Shumpei; Matsuyama, Tsuyoshi; Ditzer, Oliver; Islam, Md Sirajul; Ohya, Yuichi; Sada, Kazuki; Konagaya, Akihiko; Kuzuya, Akinori; Kakugo, Akira.
Affiliation
  • Akamatsu N; Department of Chemistry and Materials Engineering , Kansai University , Osaka 564-8680 , Japan.
  • Ishikawa S; Department of Chemistry and Materials Engineering , Kansai University , Osaka 564-8680 , Japan.
  • Matsuyama T; Department of Chemistry and Materials Engineering , Kansai University , Osaka 564-8680 , Japan.
  • Ditzer O; Faculty of Chemistry and Food Chemistry , Technische Universität Dresden , Prüfungsamt, 01062 Dresden , Germany.
  • Islam MS; Organization for Research and Development of Innovative Science and Technology , Kansai University , Osaka 564-8680 , Japan.
  • Ohya Y; Department of Chemistry and Materials Engineering , Kansai University , Osaka 564-8680 , Japan.
  • Sada K; Organization for Research and Development of Innovative Science and Technology , Kansai University , Osaka 564-8680 , Japan.
  • Kuzuya A; Department of Computational Intelligence and Systems Science , Tokyo Institute of Technology , Kanagawa 226-8502 , Japan.
  • Kakugo A; Department of Chemistry and Materials Engineering , Kansai University , Osaka 564-8680 , Japan.
Nano Lett ; 19(6): 3933-3938, 2019 06 12.
Article in En | MEDLINE | ID: mdl-31037942
ABSTRACT
DNA has been well-known for its applications in programmable self-assembly of materials. Nonetheless, utility of DNA origami, which offers more opportunity to realize complicated operations, has been very limited. Here we report self-assembly of a biomolecular motor system, microtubule-kinesin mediated by DNA origami nanostructures. We demonstrate that a rodlike DNA origami motif facilitates self-assembly of microtubules into asters. A smooth-muscle like molecular contraction system has also been realized using the DNA origami in which self-assembled microtubules exhibited fast and dynamic contraction in the presence of kinesins through an energy dissipative process. This work provides potential nanotechnological applications of DNA and biomolecular motor proteins.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA / Kinesins / Nanostructures / Microtubules Language: En Journal: Nano Lett Year: 2019 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA / Kinesins / Nanostructures / Microtubules Language: En Journal: Nano Lett Year: 2019 Document type: Article