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Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections.
Bakowski, Malina A; Shiroodi, Roohollah Kazem; Liu, Renhe; Olejniczak, Jason; Yang, Baiyuan; Gagaring, Kerstin; Guo, Hui; White, Pamela M; Chappell, Laura; Debec, Alain; Landmann, Frédéric; Dubben, Bettina; Lenz, Franziska; Struever, Dominique; Ehrens, Alexandra; Frohberger, Stefan J; Sjoberg, Hanna; Pionnier, Nicolas; Murphy, Emma; Archer, John; Steven, Andrew; Chunda, Valerine C; Fombad, Fanny F; Chounna, Patrick W; Njouendou, Abdel J; Metuge, Haelly M; Ndzeshang, Bertrand L; Gandjui, Narcisse V; Akumtoh, Desmond N; Kwenti, Tayong D B; Woods, Ashley K; Joseph, Sean B; Hull, Mitchell V; Xiong, Wen; Kuhen, Kelli L; Taylor, Mark J; Wanji, Samuel; Turner, Joseph D; Hübner, Marc P; Hoerauf, Achim; Chatterjee, Arnab K; Roland, Jason; Tremblay, Matt S; Schultz, Peter G; Sullivan, William; Chu, Xin-Jie; Petrassi, H Michael; McNamara, Case W.
Affiliation
  • Bakowski MA; Calibr at Scripps Research, La Jolla, CA 92037, USA.
  • Shiroodi RK; Calibr at Scripps Research, La Jolla, CA 92037, USA.
  • Liu R; Global Health Drug Discovery Institute (GHDDI), Beijing, China.
  • Olejniczak J; Calibr at Scripps Research, La Jolla, CA 92037, USA.
  • Yang B; Calibr at Scripps Research, La Jolla, CA 92037, USA.
  • Gagaring K; Calibr at Scripps Research, La Jolla, CA 92037, USA.
  • Guo H; Calibr at Scripps Research, La Jolla, CA 92037, USA.
  • White PM; University of California Santa Cruz, Santa Cruz, CA 95064, USA.
  • Chappell L; University of California Santa Cruz, Santa Cruz, CA 95064, USA.
  • Debec A; Jacques Monod Institute, University Paris Diderot/CNRS, 75013 Paris, France.
  • Landmann F; CRBM, University of Montpellier, CNRS, Montpellier, France.
  • Dubben B; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
  • Lenz F; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
  • Struever D; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
  • Ehrens A; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
  • Frohberger SJ; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
  • Sjoberg H; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.
  • Pionnier N; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.
  • Murphy E; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.
  • Archer J; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.
  • Steven A; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.
  • Chunda VC; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.
  • Fombad FF; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.
  • Chounna PW; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.
  • Njouendou AJ; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.
  • Metuge HM; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.
  • Ndzeshang BL; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.
  • Gandjui NV; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.
  • Akumtoh DN; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.
  • Kwenti TDB; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.
  • Woods AK; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.
  • Joseph SB; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.
  • Hull MV; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.
  • Xiong W; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.
  • Kuhen KL; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.
  • Taylor MJ; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.
  • Wanji S; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.
  • Turner JD; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.
  • Hübner MP; Calibr at Scripps Research, La Jolla, CA 92037, USA.
  • Hoerauf A; Calibr at Scripps Research, La Jolla, CA 92037, USA.
  • Chatterjee AK; Calibr at Scripps Research, La Jolla, CA 92037, USA.
  • Roland J; Global Health Drug Discovery Institute (GHDDI), Beijing, China.
  • Tremblay MS; Calibr at Scripps Research, La Jolla, CA 92037, USA.
  • Schultz PG; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.
  • Sullivan W; Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.
  • Chu XJ; Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.
  • Petrassi HM; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.
  • McNamara CW; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
Sci Transl Med ; 11(491)2019 05 08.
Article in En | MEDLINE | ID: mdl-31068442
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Drug Discovery / Filariasis / Filarioidea / Anti-Bacterial Agents Limits: Animals Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2019 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Drug Discovery / Filariasis / Filarioidea / Anti-Bacterial Agents Limits: Animals Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2019 Document type: Article Affiliation country: Country of publication: