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Mono-methylindoles induce CYP1A genes and inhibit CYP1A1 enzyme activity in human hepatocytes and HepaRG cells.
Vyhlídalová, Barbora; Poulíková, Karolína; Bartonková, Iveta; Krasulová, Kristýna; Vanco, Jan; Trávnícek, Zdenek; Mani, Sridhar; Dvorák, Zdenek.
Affiliation
  • Vyhlídalová B; Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtitelu 27, 783 71, Olomouc, Czech Republic.
  • Poulíková K; Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtitelu 27, 783 71, Olomouc, Czech Republic.
  • Bartonková I; Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtitelu 27, 783 71, Olomouc, Czech Republic.
  • Krasulová K; Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtitelu 27, 783 71, Olomouc, Czech Republic; Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacky University, Slechtitelu 27, 783 71, Olomouc, Czech Republic.
  • Vanco J; Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacky University, Slechtitelu 27, 783 71, Olomouc, Czech Republic.
  • Trávnícek Z; Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacky University, Slechtitelu 27, 783 71, Olomouc, Czech Republic.
  • Mani S; Department of Genetics and Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
  • Dvorák Z; Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtitelu 27, 783 71, Olomouc, Czech Republic; Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacky University, Slechtitelu 27, 783 71, Olomouc, Czech Republic. Electronic address: zdene
Toxicol Lett ; 313: 66-76, 2019 Oct 01.
Article in En | MEDLINE | ID: mdl-31201936
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytochrome P-450 CYP1A1 / Hepatocytes / Cytochrome P-450 Enzyme Inducers / Cytochrome P-450 Enzyme Inhibitors / Indoles Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Toxicol Lett Year: 2019 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytochrome P-450 CYP1A1 / Hepatocytes / Cytochrome P-450 Enzyme Inducers / Cytochrome P-450 Enzyme Inhibitors / Indoles Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Toxicol Lett Year: 2019 Document type: Article Affiliation country: Country of publication: