Resting-state dynamics as a neuromarker of dopamine administration in healthy female adults.
J Psychopharmacol
; 33(8): 955-964, 2019 08.
Article
in En
| MEDLINE
| ID: mdl-31246145
ABSTRACT
BACKGROUND:
Different neuromarkers of people's emotions, personality traits and behavioural performance have recently been identified. However, not much attention has been devoted to neuromarkers of neural responsiveness to drug administration.AIMS:
We investigated the predictive neuromarkers of acute dopamine (DA) administration.METHODS:
In a double-blind, within-subject study, we administrated a DA agonist (pramipexole) or placebo to 27 healthy female subjects. Using multivariate classification and prediction analyses, we examined whether dopaminergic modulations of task-free resting-state brain dynamics predict individual differences in pramipexole's modulation of facial attractiveness evaluations.RESULTS:
Our results demonstrate that pramipexole's effects on brain dynamics could be successfully discriminated from resting-state functional connectivity (accuracy 78.9%; p < 0.0001). On the behavioural level, pramipexole increased facial attractiveness evaluations (t(39) = 4.44; p < 0.0001). In particular, pramipexole administration enhanced connectivity strength of the cinguloopercular network (t(23) = 3.29; p = 0.003) and increased brain signal variability in subcortical and prefrontal brain areas (t(13) = 3.05, p = 0.009). Importantly, multivariate predictive models reveal that pramipexole-dependent modulation of resting-state dynamics predicted the increase of facial attractiveness evaluations after pramipexole (connectivity strength standardized mean squared error, smse = 0.65; p = 0.0007; brain signal variability smse = 0.94, p = 0.015).CONCLUSION:
These results demonstrate that modulations of resting-state brain dynamics induced by a DA agonist predict drug-related effects on evaluation processes, providing a neuromarker of the neural responsiveness of specific brain networks to DA administration.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rest
/
Dopamine
Type of study:
Clinical_trials
/
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
J Psychopharmacol
Journal subject:
PSICOFARMACOLOGIA
Year:
2019
Document type:
Article
Affiliation country: