Small for gestational age very preterm infants present a higher risk of developing bronchopulmonary dysplasia.
J Neonatal Perinatal Med
; 12(4): 419-427, 2019.
Article
in En
| MEDLINE
| ID: mdl-31256077
ABSTRACT
INTRODUCTION:
Several studies assessed the influence of a low birth weight on bronchopulmonary dysplasia (BPD), but not all could find a significant association. Our aim was to assess the association between low birth weight and BPD in preterm infants, prospectively recruited at 11 level III Portuguese neonatal centers.METHODS:
Obstetrical and neonatal data on mothers and preterm infants with gestational ages between 24 and 30 weeks, born during 2015 and 2016 after a surveilled pregnancy, were analyzed. Neonates were considered small for gestational age (SGA) when their birthweight was below the 10th centile of Fenton's growth chats and BPD was defined as the dependency for oxygen therapy until 36 weeks of corrected age. Statistical analysis was performed using IBM SPSS® statistics 23 and a p-value <0.05 was considered statistically significant.RESULTS:
Out of 614, a total of 494 preterm infants delivered from 410 women were enrolled in the study; 40 (8.0%) infants with SGA criteria. SGA were more often associated with a single pregnancy, had greater use of antenatal corticosteroids, increased prevalence of gestational hypertensive disorders, C-section, rupture of membranes below 18 hours, rate of intubation in the delivery room, use of surfactant treatment, oxygen therapy, mechanical ventilation need, BPD, cystic periventricular leukomalacia, nosocomial sepsis and pneumonia; had lower prevalence of chorioamnionitis, and lower Apgar scores. The multivariate analysis by logistic regression, adjusted for BPD risk factors revealed a significant association between SGA and BPD ORâ=â5.2 [CI 1.46-18.58]; pâ=â0.01.CONCLUSION:
The results of this study increase the scientific evidence that SGA is an independent risk factor for BPD.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Respiration, Artificial
/
Pulmonary Surfactants
/
Bronchopulmonary Dysplasia
/
Infant, Premature, Diseases
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Newborn
Country/Region as subject:
Europa
Language:
En
Journal:
J Neonatal Perinatal Med
Year:
2019
Document type:
Article
Affiliation country: