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Investigation of the role of typhoid toxin in acute typhoid fever in a human challenge model.
Gibani, Malick M; Jones, Elizabeth; Barton, Amber; Jin, Celina; Meek, Juliette; Camara, Susana; Galal, Ushma; Heinz, Eva; Rosenberg-Hasson, Yael; Obermoser, Gerlinde; Jones, Claire; Campbell, Danielle; Black, Charlotte; Thomaides-Brears, Helena; Darlow, Christopher; Dold, Christina; Silva-Reyes, Laura; Blackwell, Luke; Lara-Tejero, Maria; Jiao, Xuyao; Stack, Gabrielle; Blohmke, Christoph J; Hill, Jennifer; Angus, Brian; Dougan, Gordon; Galán, Jorge; Pollard, Andrew J.
Affiliation
  • Gibani MM; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK. malick.gibani@paediatrics.ox.ac.uk.
  • Jones E; Department of Medicine, Imperial College London, London, UK. malick.gibani@paediatrics.ox.ac.uk.
  • Barton A; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Jin C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Meek J; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Camara S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Galal U; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Heinz E; Nuffield Department of Primary Care Health Sciences, Clinical Trials Unit, University of Oxford, Oxford, UK.
  • Rosenberg-Hasson Y; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
  • Obermoser G; Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK.
  • Jones C; Human Immune Monitoring Center, Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
  • Campbell D; Human Immune Monitoring Center, Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
  • Black C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Thomaides-Brears H; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Darlow C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Dold C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Silva-Reyes L; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Blackwell L; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Lara-Tejero M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Jiao X; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Stack G; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.
  • Blohmke CJ; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.
  • Hill J; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.
  • Angus B; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Dougan G; Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Galán J; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Pollard AJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Nat Med ; 25(7): 1082-1088, 2019 07.
Article in En | MEDLINE | ID: mdl-31270506

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Salmonella typhi / Bacterial Toxins / Typhoid Fever Type of study: Clinical_trials Limits: Adolescent / Adult / Animals / Humans / Middle aged Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2019 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Salmonella typhi / Bacterial Toxins / Typhoid Fever Type of study: Clinical_trials Limits: Adolescent / Adult / Animals / Humans / Middle aged Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2019 Document type: Article Affiliation country: Country of publication: