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CRISPR-Cas9-mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes.
Takeda, Haruna; Kataoka, Shiho; Nakayama, Mizuho; Ali, Mohamed A E; Oshima, Hiroko; Yamamoto, Daisuke; Park, Jun-Won; Takegami, Yujiro; An, Tadaichi; Jenkins, Nancy A; Copeland, Neal G; Oshima, Masanobu.
Affiliation
  • Takeda H; Cancer Genes and Genomes Unit, Cancer Research Institute, Kanazawa University, 920-1192 Kanazawa, Ishikawa, Japan; hartaked@ncc.go.jp ncopeland1@mdanderson.org.
  • Kataoka S; Cancer Genes and Genomes Unit, Cancer Research Institute, Kanazawa University, 920-1192 Kanazawa, Ishikawa, Japan.
  • Nakayama M; Division of Genetics, Cancer Research Institute, Kanazawa University, 920-1192 Kanazawa, Ishikawa, Japan.
  • Ali MAE; Nano-Life Science Institute, Kanazawa University, 920-1192 Kanazawa, Ishikawa, Japan.
  • Oshima H; Division of Experimental Therapeutics, Cancer Research Institute, Kanazawa University, 920-1192 Kanazawa, Ishikawa, Japan.
  • Yamamoto D; Division of Genetics, Cancer Research Institute, Kanazawa University, 920-1192 Kanazawa, Ishikawa, Japan.
  • Park JW; Nano-Life Science Institute, Kanazawa University, 920-1192 Kanazawa, Ishikawa, Japan.
  • Takegami Y; Division of Genetics, Cancer Research Institute, Kanazawa University, 920-1192 Kanazawa, Ishikawa, Japan.
  • An T; Department of Gastroenterological Surgery, Ishikawa Prefectural Central Hospital, 920-8530 Kanazawa, Ishikawa, Japan.
  • Jenkins NA; Division of Genetics, Cancer Research Institute, Kanazawa University, 920-1192 Kanazawa, Ishikawa, Japan.
  • Copeland NG; DNAFORM Precision Gene Technologies, 230-0046 Yokohama, Kanagawa, Japan.
  • Oshima M; DNAFORM Precision Gene Technologies, 230-0046 Yokohama, Kanagawa, Japan.
Proc Natl Acad Sci U S A ; 116(31): 15635-15644, 2019 07 30.
Article in En | MEDLINE | ID: mdl-31300537
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Organoids / Gene Expression Profiling / Gene Knockout Techniques / CRISPR-Cas Systems / Neoplasm Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2019 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Organoids / Gene Expression Profiling / Gene Knockout Techniques / CRISPR-Cas Systems / Neoplasm Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2019 Document type: Article Country of publication: