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Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations.
de Wispelaere, Mélissanne; Du, Guangyan; Donovan, Katherine A; Zhang, Tinghu; Eleuteri, Nicholas A; Yuan, Jingting C; Kalabathula, Joann; Nowak, Radoslaw P; Fischer, Eric S; Gray, Nathanael S; Yang, Priscilla L.
Affiliation
  • de Wispelaere M; Department of Microbiology and Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA.
  • Du G; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.
  • Donovan KA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
  • Zhang T; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.
  • Eleuteri NA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
  • Yuan JC; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.
  • Kalabathula J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
  • Nowak RP; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
  • Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
  • Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
  • Yang PL; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.
Nat Commun ; 10(1): 3468, 2019 08 01.
Article in En | MEDLINE | ID: mdl-31371704
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Protease Inhibitors / Viral Nonstructural Proteins / Drug Resistance, Viral / Intracellular Signaling Peptides and Proteins Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Protease Inhibitors / Viral Nonstructural Proteins / Drug Resistance, Viral / Intracellular Signaling Peptides and Proteins Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Document type: Article Affiliation country: Country of publication: