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A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases.
Nishimiya, Daisuke; Kawaguchi, Yoshirou; Kodama, Shiho; Nasu, Hatsumi; Yano, Hidenori; Yamaguchi, Aya; Tamura, Masakazu; Hashimoto, Ryuji.
Affiliation
  • Nishimiya D; DAIICHI SANKYO CO., LTD., Biologics Division, Modality Research Laboratories, 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan. nishimiya.daisuke.tc@daiichisankyo.co.jp.
  • Kawaguchi Y; DAIICHI SANKYO CO., LTD., Biologics Division, Modality Research Laboratories, 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.
  • Kodama S; DAIICHI SANKYO CO., LTD., Biologics Division, Modality Research Laboratories, 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.
  • Nasu H; DAIICHI SANKYO CO., LTD., Biologics Division, Modality Research Laboratories, 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.
  • Yano H; DAIICHI SANKYO CO., LTD., Biologics Division, Modality Research Laboratories, 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.
  • Yamaguchi A; DAIICHI SANKYO CO., LTD., Biologics Division, Modality Research Laboratories, 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.
  • Tamura M; DAIICHI SANKYO CO., LTD., Biologics Division, Modality Research Laboratories, 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.
  • Hashimoto R; DAIICHI SANKYO CO., LTD., Biologics Division, Modality Research Laboratories, 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.
Sci Rep ; 9(1): 11436, 2019 08 07.
Article in En | MEDLINE | ID: mdl-31391482
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glycoproteins / Drug Design / Protein Engineering / Serine Proteinase Inhibitors / Mutagenesis / Serine Peptidase Inhibitors, Kazal Type Language: En Journal: Sci Rep Year: 2019 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glycoproteins / Drug Design / Protein Engineering / Serine Proteinase Inhibitors / Mutagenesis / Serine Peptidase Inhibitors, Kazal Type Language: En Journal: Sci Rep Year: 2019 Document type: Article Affiliation country: Country of publication: