Multimodal Imaging of Multiple Evanescent White Dot Syndrome: A New Interpretation.
Ocul Immunol Inflamm
; 28(5): 814-820, 2020 Jul 03.
Article
in En
| MEDLINE
| ID: mdl-31414928
ABSTRACT
PURPOSE:
To investigate the pathogenesis of Multiple Evanescent White Dot Syndrome (MEWDS) using multimodal imaging (MMI).METHODS:
Retrospective case series of 7 patients with acute MEWDS. Each patient underwent near-infrared reflectance (IR), blue and near-infrared autofluorescence (FAF and NIRAF), fluorescein angiography (FA), indocyanine green angiography (ICGA), enhanced depth imaging optical coherence tomography (EDI-OCT) on Spectralis, and optical coherence tomography angiography on OCTA Spectralis, XR Avanti or Plex Elite 9000.RESULTS:
OCTA and FA findings of early hyperfluorescence depict an unaffected choriocapillaris. On ICGA early to late hypofluorescent lesions corresponded to the hyporeflectivity on IR, consistent with altered reflectivity of the RPE. The SDI-OCT showed ellipsoid zone disruption as confirmed by FAF hyperautofluorescence. Some lesions showed a hypertransmission sign underneath the RPE, possibly due to changes in RPE intracellular melanin as suggested by NIRAF hypoautofluorescence.CONCLUSIONS:
The MMI findings of MEWDS are secondary to RPE reflectivity changes, suggesting its pivotal role.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Retinal Pigment Epithelium
/
Multimodal Imaging
/
White Dot Syndromes
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Ocul Immunol Inflamm
Journal subject:
ALERGIA E IMUNOLOGIA
/
OFTALMOLOGIA
Year:
2020
Document type:
Article
Affiliation country: