Re-positioning of known drugs for Pim-1 kinase target using molecular docking analysis.
Bioinformation
; 15(2): 116-120, 2019.
Article
in En
| MEDLINE
| ID: mdl-31435157
ABSTRACT
The Concept of reusing existing drugs for new targets is gaining momentum in recent years because of cost-effectiveness as safety and toxicology data are already available. Therefore, it is of interest to re-profile known drugs against the Pim-1 kinase target using molecular docking analysis. Results show that known drugs such as nilotinib, vemurafenib, Idelalisib, and other small kinases inhibitors have high binding ability with Pim-1 kinase for consideration as potential inhibitors.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Bioinformation
Year:
2019
Document type:
Article