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New 8-Hydroxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae).
Chen, You-Ying; Fang, Lee-Shing; Chen, Yu-Hsin; Peng, Bo-Rong; Su, Tung-Pin; Huynh, Thanh-Hao; Lin, Feng-Yu; Hu, Chiung-Chin; Lin, Nai-Cheng; Wen, Zhi-Hong; Chen, Jih-Jung; Lee, Chieh-Yu; Wang, Jin-Wei; Sung, Ping-Jyun.
Affiliation
  • Chen YY; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. zoeblack0108@gmail.com.
  • Fang LS; National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. zoeblack0108@gmail.com.
  • Chen YH; Center for Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung 833, Taiwan. lsfang@csu.edu.tw.
  • Peng BR; Super Micro Mass Research and Technology Center, Cheng Shiu University, Kaohsiung 833, Taiwan. lsfang@csu.edu.tw.
  • Su TP; National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. kb5634@yahoo.com.tw.
  • Huynh TH; National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. pengpojung@gmail.com.
  • Lin FY; Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pengpojung@gmail.com.
  • Hu CC; Doctoral Degree Program in Marine Biotechnology, Academia Sinica, Taipei 115, Taiwan. pengpojung@gmail.com.
  • Lin NC; National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. g3xz84120@yahoo.com.tw.
  • Wen ZH; Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. g3xz84120@yahoo.com.tw.
  • Chen JJ; National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. haohuynh0108@gmail.com.
  • Lee CY; Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. haohuynh0108@gmail.com.
  • Wang JW; National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. fengyu30658252@gmail.com.
  • Sung PJ; Department of Applied Chemistry, National Pingtung University, Pingtung 900, Taiwan. fengyu30658252@gmail.com.
Mar Drugs ; 17(9)2019 Sep 14.
Article in En | MEDLINE | ID: mdl-31540107
ABSTRACT
Three new 8-hydroxybriaranes-fragilides R-T (1-3) were obtained from a sea whip gorgonian coral Junceella fragilis. The structures of briaranes 1-3 were elucidated by using spectroscopic methods, including 1D (1H and 13C NMR), 2D (COSY, HSQC, HMBC, and NOESY experiments) NMR studies, and (+)-HRESIMS. Fragilides S and T (2 and 3) are the only briaranes known to possess 8α-hydroxy and 17ß-methyl groups, respectively. Briarane 2 exerted an inhibition effect on iNOS release from RAW264.7; a macrophage cell line that originated from a mouse monocyte macrophage, stimulated with lipopolysaccharides.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anthozoa / Diterpenes / Anti-Inflammatory Agents Limits: Animals Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2019 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anthozoa / Diterpenes / Anti-Inflammatory Agents Limits: Animals Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2019 Document type: Article Affiliation country: