Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis.
Cells
; 8(9)2019 09 13.
Article
in En
| MEDLINE
| ID: mdl-31540207
ABSTRACT
We recently observed reduced autophagy in Crohn's disease patients and an anti-inflammatory effect of autophagy stimulation in murine colitis, but both anti- and pro-fibrotic effects are associated with autophagy stimulation in different tissues, and fibrosis is a frequent complication of Crohn's disease. Thus, we analyzed the effects of pharmacological modulation of autophagy in a murine model of intestinal fibrosis and detected that autophagy inhibition aggravates, while autophagy stimulation prevents, fibrosis. These effects are associated with changes in inflammation and in collagen degradation in primary fibroblasts. Thus, pharmacological stimulation of autophagy may be useful against intestinal fibrosis.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autophagy
/
Fibrosis
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Fibroblasts
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Immunosuppressive Agents
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Inflammation
/
Intestines
Limits:
Animals
Language:
En
Journal:
Cells
Year:
2019
Document type:
Article
Affiliation country: