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Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor).
Ben Djoudi Ouadda, Ali; Gauthier, Marie-Soleil; Susan-Resiga, Delia; Girard, Emmanuelle; Essalmani, Rachid; Black, Miles; Marcinkiewicz, Jadwiga; Forget, Diane; Hamelin, Josée; Evagelidis, Alexandra; Ly, Kevin; Day, Robert; Galarneau, Luc; Corbin, Francois; Coulombe, Benoit; Çaku, Artuela; Tagliabracci, Vincent S; Seidah, Nabil G.
Affiliation
  • Ben Djoudi Ouadda A; From the Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM; affiliated to the Université de Montréal), QC, Canada (A.B.D.O., D.S.-R., E.G., R.E., J.M., J.H., A.E., N.G.S.).
  • Gauthier MS; Translational Proteomics Research Unit, Clinical Research Institute of Montreal (IRCM, affiliated to the Université de Montréal), QC, Canada (M.-S.G., D.F., B.C.).
  • Susan-Resiga D; From the Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM; affiliated to the Université de Montréal), QC, Canada (A.B.D.O., D.S.-R., E.G., R.E., J.M., J.H., A.E., N.G.S.).
  • Girard E; From the Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM; affiliated to the Université de Montréal), QC, Canada (A.B.D.O., D.S.-R., E.G., R.E., J.M., J.H., A.E., N.G.S.).
  • Essalmani R; From the Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM; affiliated to the Université de Montréal), QC, Canada (A.B.D.O., D.S.-R., E.G., R.E., J.M., J.H., A.E., N.G.S.).
  • Black M; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas (M.B., V.S.T.).
  • Marcinkiewicz J; From the Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM; affiliated to the Université de Montréal), QC, Canada (A.B.D.O., D.S.-R., E.G., R.E., J.M., J.H., A.E., N.G.S.).
  • Forget D; Translational Proteomics Research Unit, Clinical Research Institute of Montreal (IRCM, affiliated to the Université de Montréal), QC, Canada (M.-S.G., D.F., B.C.).
  • Hamelin J; From the Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM; affiliated to the Université de Montréal), QC, Canada (A.B.D.O., D.S.-R., E.G., R.E., J.M., J.H., A.E., N.G.S.).
  • Evagelidis A; From the Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM; affiliated to the Université de Montréal), QC, Canada (A.B.D.O., D.S.-R., E.G., R.E., J.M., J.H., A.E., N.G.S.).
  • Ly K; Institut de Pharmacologie, Université de Sherbrooke, QC, Canada (K.L., R.D.).
  • Day R; Institut de Pharmacologie, Université de Sherbrooke, QC, Canada (K.L., R.D.).
  • Galarneau L; Department of Biochemistry, Université de Sherbrooke, and Centre de Recherche du CHUS, QC, Canada (L.G., F.C., A.Ç.).
  • Corbin F; Department of Biochemistry, Université de Sherbrooke, and Centre de Recherche du CHUS, QC, Canada (L.G., F.C., A.Ç.).
  • Coulombe B; Translational Proteomics Research Unit, Clinical Research Institute of Montreal (IRCM, affiliated to the Université de Montréal), QC, Canada (M.-S.G., D.F., B.C.).
  • Çaku A; Department of Biochemistry, Université de Sherbrooke, and Centre de Recherche du CHUS, QC, Canada (L.G., F.C., A.Ç.).
  • Tagliabracci VS; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas (M.B., V.S.T.).
  • Seidah NG; From the Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM; affiliated to the Université de Montréal), QC, Canada (A.B.D.O., D.S.-R., E.G., R.E., J.M., J.H., A.E., N.G.S.).
Arterioscler Thromb Vasc Biol ; 39(10): 1996-2013, 2019 10.
Article in En | MEDLINE | ID: mdl-31553664
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcium-Binding Proteins / Receptors, LDL / Gene Expression Regulation / Extracellular Matrix Proteins / Proprotein Convertase 9 / Hyperlipoproteinemia Type II Type of study: Diagnostic_studies Limits: Animals / Humans / Male Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2019 Document type: Article Country of publication:
Fulltext
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Print
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcium-Binding Proteins / Receptors, LDL / Gene Expression Regulation / Extracellular Matrix Proteins / Proprotein Convertase 9 / Hyperlipoproteinemia Type II Type of study: Diagnostic_studies Limits: Animals / Humans / Male Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2019 Document type: Article Country of publication: