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Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology.
Takeda, Andrew J; Maher, Timothy J; Zhang, Yu; Lanahan, Stephen M; Bucklin, Molly L; Compton, Susan R; Tyler, Paul M; Comrie, William A; Matsuda, Makoto; Olivier, Kenneth N; Pittaluga, Stefania; McElwee, Joshua J; Long Priel, Debra A; Kuhns, Douglas B; Williams, Roger L; Mustillo, Peter J; Wymann, Matthias P; Koneti Rao, V; Lucas, Carrie L.
Affiliation
  • Takeda AJ; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
  • Maher TJ; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
  • Zhang Y; Clinical Genomics Program and Molecular Development of the Immune System Section, Laboratory of Immunology, NIAID, NIH, Bethesda, MD, USA.
  • Lanahan SM; Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA.
  • Bucklin ML; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
  • Compton SR; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
  • Tyler PM; Department of Comparative Medicine, Yale University, New Haven, CT, USA.
  • Comrie WA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
  • Matsuda M; Clinical Genomics Program and Molecular Development of the Immune System Section, Laboratory of Immunology, NIAID, NIH, Bethesda, MD, USA.
  • Olivier KN; Laboratory of Molecular Biology, Medical Research Council, Cambridge, UK.
  • Pittaluga S; Pulmonary Branch, Division of Intramural Research, NHLBI, NIH, Bethesda, MD, USA.
  • McElwee JJ; Laboratory of Pathology, Clinical Center, NCI, NIH, Bethesda, MD, USA.
  • Long Priel DA; Merck Research Laboratories, Merck & Co, Boston, MA, USA.
  • Kuhns DB; Neutrophil Monitoring Laboratory, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Williams RL; Neutrophil Monitoring Laboratory, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Mustillo PJ; Laboratory of Molecular Biology, Medical Research Council, Cambridge, UK.
  • Wymann MP; Division of Infectious Diseases and Immunology, Nationwide Children's Hospital, Columbus, OH, USA.
  • Koneti Rao V; University of Basel, Department of Biomedicine, Basel, Switzerland.
  • Lucas CL; Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA.
Nat Commun ; 10(1): 4364, 2019 09 25.
Article in En | MEDLINE | ID: mdl-31554793
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adaptive Immunity / Class Ib Phosphatidylinositol 3-Kinase / Microbiota / Immunologic Deficiency Syndromes / Inflammation Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adaptive Immunity / Class Ib Phosphatidylinositol 3-Kinase / Microbiota / Immunologic Deficiency Syndromes / Inflammation Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Document type: Article Affiliation country: Country of publication: