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E3 ligase RCHY1 negatively regulates HDAC2.
Choi, Mina; Choi, Yeong Min; An, In-Sook; Bae, Seunghee; Jung, Jin Hyuk; An, Sungkwan.
Affiliation
  • Choi M; Research Institute for Molecular-Targeted Drugs, Department of Cosmetics Engineering, Konkuk University, Seoul, 05029, South Korea.
  • Choi YM; Korea Institute of Dermatological Science, GeneCellPharm Corporation, 375 Munjeong 2(i)-dong, Songpa-gu Seoul, 05836, South Korea.
  • An IS; Korea Institute of Dermatological Science, GeneCellPharm Corporation, 375 Munjeong 2(i)-dong, Songpa-gu Seoul, 05836, South Korea.
  • Bae S; Research Institute for Molecular-Targeted Drugs, Department of Cosmetics Engineering, Konkuk University, Seoul, 05029, South Korea.
  • Jung JH; Korea Institute of Dermatological Science, GeneCellPharm Corporation, 375 Munjeong 2(i)-dong, Songpa-gu Seoul, 05836, South Korea. Electronic address: jungjh@skinreseach.or.kr.
  • An S; Research Institute for Molecular-Targeted Drugs, Department of Cosmetics Engineering, Konkuk University, Seoul, 05029, South Korea. Electronic address: ansungkwan@konkuk.ac.kr.
Biochem Biophys Res Commun ; 521(1): 37-41, 2020 01 01.
Article in En | MEDLINE | ID: mdl-31630802
ABSTRACT
HDAC2, one of the class I histone deacetylase regulates epigenetic landscape through histone modification. Because HDAC2 is overexpressed in many cancers, cancer therapeutics against HDAC2 have been developed. Here we show novel mechanism of HDAC2 regulation by E3 ligase RCHY1. We found inverse correlation RCHY1 and HDAC2 levels in tumor tissue from six independent dataset using meta-analysis. Ectopic expression of RCHY1 decreased the level of HDAC2 from cancer cells including p53 wildtype, mutant and null cells. In addition, HDAC2 was increased by RCHY1 knockdown. RCHY1 directly interacts with HDAC2. Ectopic expression of wild type but not RING mutant RCHY1 increased HDAC2 levels. These data provide an evidence that RCHY1 negatively regulates HDAC2.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ubiquitin-Protein Ligases / Histone Deacetylase 2 Limits: Animals / Humans Language: En Journal: Biochem Biophys Res Commun Year: 2020 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ubiquitin-Protein Ligases / Histone Deacetylase 2 Limits: Animals / Humans Language: En Journal: Biochem Biophys Res Commun Year: 2020 Document type: Article Affiliation country: