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Synthesis and Pharmacological Evaluation of Triazolopyrimidinone Derivatives as Noncompetitive, Intracellular Antagonists for CC Chemokine Receptors 2 and 5.
Ortiz Zacarías, Natalia V; van Veldhoven, Jacobus P D; den Hollander, Lisa S; Dogan, Burak; Openy, Joseph; Hsiao, Ya-Yun; Lenselink, Eelke B; Heitman, Laura H; IJzerman, Adriaan P.
Affiliation
  • Ortiz Zacarías NV; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research , Leiden University , P.O. Box 9502, 2300 RA Leiden , The Netherlands.
  • van Veldhoven JPD; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research , Leiden University , P.O. Box 9502, 2300 RA Leiden , The Netherlands.
  • den Hollander LS; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research , Leiden University , P.O. Box 9502, 2300 RA Leiden , The Netherlands.
  • Dogan B; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research , Leiden University , P.O. Box 9502, 2300 RA Leiden , The Netherlands.
  • Openy J; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research , Leiden University , P.O. Box 9502, 2300 RA Leiden , The Netherlands.
  • Hsiao YY; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research , Leiden University , P.O. Box 9502, 2300 RA Leiden , The Netherlands.
  • Lenselink EB; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research , Leiden University , P.O. Box 9502, 2300 RA Leiden , The Netherlands.
  • Heitman LH; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research , Leiden University , P.O. Box 9502, 2300 RA Leiden , The Netherlands.
  • IJzerman AP; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research , Leiden University , P.O. Box 9502, 2300 RA Leiden , The Netherlands.
J Med Chem ; 62(24): 11035-11053, 2019 12 26.
Article in En | MEDLINE | ID: mdl-31742400

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Purines / Receptors, CCR5 / Cell Proliferation / Receptors, CCR2 / Antineoplastic Agents Type of study: Evaluation_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2019 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Purines / Receptors, CCR5 / Cell Proliferation / Receptors, CCR2 / Antineoplastic Agents Type of study: Evaluation_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2019 Document type: Article Affiliation country: Country of publication: