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MIF -173G/C polymorphism is associated with NMO disease severity.
Brill, Livnat; Vaknin-Dembinsky, Adi; Zveik, Omri; Haham, Nitsan; Miller, Keren; Benedek, Gil.
Affiliation
  • Brill L; Department of Neurology and Laboratory of Neuroimmunology, and the Agnes-Ginges Center for Neurogenetics, Hadassah Medical Center, Hebrew University of Jerusalem, The Faculty of Medicine, Israel.
  • Vaknin-Dembinsky A; Department of Neurology and Laboratory of Neuroimmunology, and the Agnes-Ginges Center for Neurogenetics, Hadassah Medical Center, Hebrew University of Jerusalem, The Faculty of Medicine, Israel.
  • Zveik O; Department of Neurology and Laboratory of Neuroimmunology, and the Agnes-Ginges Center for Neurogenetics, Hadassah Medical Center, Hebrew University of Jerusalem, The Faculty of Medicine, Israel.
  • Haham N; Department of Neurology and Laboratory of Neuroimmunology, and the Agnes-Ginges Center for Neurogenetics, Hadassah Medical Center, Hebrew University of Jerusalem, The Faculty of Medicine, Israel.
  • Miller K; Tissue Typing and Immunogenetics Laboratory, Department of Genetics, Hadassah Medical Center, Jerusalem, Israel.
  • Benedek G; Tissue Typing and Immunogenetics Laboratory, Department of Genetics, Hadassah Medical Center, Jerusalem, Israel. Electronic address: gilb@hadassah.org.il.
J Neuroimmunol ; 339: 577120, 2020 02 15.
Article in En | MEDLINE | ID: mdl-31790982
ABSTRACT
Our knowledge about genetic factors that drive the worsening of neuromyelitis optica (NMO) is limited. Herein, we analyzed the macrophage migration inhibitory factor (MIF) -173G/C functional polymorphism in NMO patients and controls. Our data reveal that the frequency of the high-expression MIF genotypes (CC/GC) did not differ between the two groups. However, frequency of this genotypes was elevated in patients diagnosed with both optic neuritis and myelitis compared with patients that were diagnosed with only one symptom. Furthermore, patients carrying the CC/CG genotypes had significantly higher disability score. We conclude that MIF is associated with NMO severity rather than susceptibility.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Severity of Illness Index / Macrophage Migration-Inhibitory Factors / Neuromyelitis Optica / Intramolecular Oxidoreductases / Polymorphism, Single Nucleotide Type of study: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Neuroimmunol Year: 2020 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Severity of Illness Index / Macrophage Migration-Inhibitory Factors / Neuromyelitis Optica / Intramolecular Oxidoreductases / Polymorphism, Single Nucleotide Type of study: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Neuroimmunol Year: 2020 Document type: Article Affiliation country: