MIF -173G/C polymorphism is associated with NMO disease severity.
J Neuroimmunol
; 339: 577120, 2020 02 15.
Article
in En
| MEDLINE
| ID: mdl-31790982
ABSTRACT
Our knowledge about genetic factors that drive the worsening of neuromyelitis optica (NMO) is limited. Herein, we analyzed the macrophage migration inhibitory factor (MIF) -173G/C functional polymorphism in NMO patients and controls. Our data reveal that the frequency of the high-expression MIF genotypes (CC/GC) did not differ between the two groups. However, frequency of this genotypes was elevated in patients diagnosed with both optic neuritis and myelitis compared with patients that were diagnosed with only one symptom. Furthermore, patients carrying the CC/CG genotypes had significantly higher disability score. We conclude that MIF is associated with NMO severity rather than susceptibility.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Severity of Illness Index
/
Macrophage Migration-Inhibitory Factors
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Neuromyelitis Optica
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Intramolecular Oxidoreductases
/
Polymorphism, Single Nucleotide
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
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Risk_factors_studies
Limits:
Adolescent
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Adult
/
Aged
/
Female
/
Humans
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Male
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Middle aged
Language:
En
Journal:
J Neuroimmunol
Year:
2020
Document type:
Article
Affiliation country: