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Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
Zhang, Hao; Zhao, Hong-Yi; Xi, Xiao-Xiao; Liu, Yan-Jie; Xin, Minhang; Mao, Shuai; Zhang, Jun-Jie; Lu, A-Xin; Zhang, San-Qi.
Affiliation
  • Zhang H; Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China.
  • Zhao HY; Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China.
  • Xi XX; Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China.
  • Liu YJ; Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China.
  • Xin M; Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China.
  • Mao S; Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China.
  • Zhang JJ; School of Science, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China.
  • Lu AX; Instrumental Analysis Center of Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China.
  • Zhang SQ; Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China. Electronic address: sqzhang@xjtu.edu.cn.
Eur J Med Chem ; 189: 112061, 2020 Mar 01.
Article in En | MEDLINE | ID: mdl-31951960
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Pyrimidines / Proteolysis / Antineoplastic Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2020 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Pyrimidines / Proteolysis / Antineoplastic Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2020 Document type: Article Country of publication: