Adult Human Glioblastomas Harbor Radial Glia-like Cells.
Stem Cell Reports
; 14(2): 338-350, 2020 02 11.
Article
in En
| MEDLINE
| ID: mdl-32004492
ABSTRACT
Radial glia (RG) cells are the first neural stem cells to appear during embryonic development. Adult human glioblastomas harbor a subpopulation of RG-like cells with typical RG morphology and markers. The cells exhibit the classic and unique mitotic behavior of normal RG in a cell-autonomous manner. Single-cell RNA sequencing analyses of glioblastoma cells reveal transcriptionally dynamic clusters of RG-like cells that share the profiles of normal human fetal radial glia and that reside in quiescent and cycling states. Functional assays show a role for interleukin in triggering exit from dormancy into active cycling, suggesting a role for inflammation in tumor progression. These data are consistent with the possibility of persistence of RG into adulthood and their involvement in tumor initiation or maintenance. They also provide a putative cellular basis for the persistence of normal developmental programs in adult tumors.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neuroglia
/
Glioblastoma
Limits:
Adult
/
Humans
Language:
En
Journal:
Stem Cell Reports
Year:
2020
Document type:
Article
Affiliation country: