Cerebrospinal fluid biomarkers implicated in the pathogenesis of anti-neutrophil cytoplasmic antibody-related hypertrophic pachymeningitis.
Clin Rheumatol
; 39(6): 1803-1811, 2020 Jun.
Article
in En
| MEDLINE
| ID: mdl-32036585
ABSTRACT
OBJECTIVE:
Hypertrophic pachymeningitis (HP) related to anti-neutrophil cytoplasmic antibody (ANCA) is the most frequently seen immune-mediated HP. We investigated cerebrospinal fluid (CSF) biomarkers related to the pathogenesis of ANCA-related HP (ANCA-HP).METHODS:
The levels of B cell activation factor of the tumor necrosis factor family (BAFF), a proliferation-inducing ligand (APRIL), and transforming growth factor beta 1 (TGF-ß1) in the CSF were compared between patients with ANCA-HP (n = 12), other types of immune-mediated HP (other HP; n = 12), multiple sclerosis (MS; n = 14), and non-inflammatory neurological disorders (NIND; n = 10). In addition, we evaluated whether ANCA would be detected in CSF.RESULTS:
CSF levels of BAFF, APRIL, and TGF-ß1 were significantly increased in ANCA-HP and other HP. In particular, BAFF and APRIL levels were significantly correlated with the IgG index in ANCA-HP. In other HP, BAFF and APRIL levels were significantly correlated with cell counts and protein levels in CSF. Of 12 patients with ANCA-HP, the CSF of 7 patients (58%) tested positive for myeloperoxidase (MPO)- or proteinase 3 (PR3)-ANCA, while none of the CSF samples from other HP, MS, or NIND patients tested positive.CONCLUSION:
The levels of BAFF, APRIL, and TGF-ß1 may serve as useful CSF biomarkers for assessing the disease activity of immune-mediated HP. Moreover, BAFF and APRIL in the CSF may be implicated in the pathogenesis of ANCA-HP via promoting autoreactive B cells, while detecting MPO- or PR3-ANCA in the CSF may be found in some patients with ANCA-HP.Key Points⢠CSF BAFF, APRIL, and TGF-ß1 levels increase significantly in immune-mediated HP.⢠CSF BAFF and APRIL levels are significantly correlated with IgG index in ANCA-HP.⢠Detection of MPO- or PR3-ANCA in the CSF is found in some patients with ANCA-HP.⢠BAFF, APRIL, and ANCA in the CSF may be implicated in the pathogenesis of ANCA-HP.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antibodies, Antineutrophil Cytoplasmic
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Transforming Growth Factor beta1
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B-Cell Activating Factor
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Tumor Necrosis Factor Ligand Superfamily Member 13
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Meningitis
Type of study:
Etiology_studies
Limits:
Adult
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Female
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Humans
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Male
/
Middle aged
Language:
En
Journal:
Clin Rheumatol
Year:
2020
Document type:
Article
Affiliation country: