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Antifungal activity of 2'-hydroxychalcone loaded in nanoemulsion against Paracoccidioides spp.
Medina-Alarcón, Kaila P; L Singulani, Junya de; Dutra, Luiz A; S Pitangui, Nayla de; Pereira-da-Silva, Marcelo A; Dos Santos, Mariana B; Ayusso, Gabriela M; Regasini, Luis O; Soares, Christiane P; Chorilli, Marlus; Mendes-Giannini, Maria Js; Fusco-Almeida, Ana M.
Affiliation
  • Medina-Alarcón KP; Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara, Proteomics Center, Mycology Laboratory, Araraquara, SP, Brazil.
  • L Singulani J; Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara, Proteomics Center, Mycology Laboratory, Araraquara, SP, Brazil.
  • Dutra LA; Structural Genomics Consortium, Research Institute-UNICAMP, Campinas, SP, Brasil.
  • S Pitangui N; Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara, Proteomics Center, Mycology Laboratory, Araraquara, SP, Brazil.
  • Pereira-da-Silva MA; Institute of Physics of Sao Carlos, IFSC/USP, Sao Carlos, SP, Brazil.
  • Dos Santos MB; Paulista Central University Center, UNICEP, Sao Carlos, SP, Brazil.
  • Ayusso GM; Universidade Estadual Paulista (UNESP), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Preto, Department of Chemistry and Environmental Sciences, São José do Rio Preto, SP, Brasil.
  • Regasini LO; Universidade Estadual Paulista (UNESP), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Preto, Department of Chemistry and Environmental Sciences, São José do Rio Preto, SP, Brasil.
  • Soares CP; Universidade Estadual Paulista (UNESP), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Preto, Department of Chemistry and Environmental Sciences, São José do Rio Preto, SP, Brasil.
  • Chorilli M; Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara, Department of Clinical Analysis, Cytology Laboratory, Araraquara, SP, Brazil.
  • Mendes-Giannini MJ; Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara, Department of Drugs and Medicines, Araraquara, SP, Brazil.
  • Fusco-Almeida AM; Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara, Proteomics Center, Mycology Laboratory, Araraquara, SP, Brazil.
Future Microbiol ; 15: 21-33, 2020 01.
Article in En | MEDLINE | ID: mdl-32043361
Aim: This study aimed to evaluate the activity of 2'-hydroxychalcone-loaded in nanoemulsion (NLS + 2'chalc), the cytotoxic effect and toxicity against Paracoccidioides brasiliensis and Paracoccidioides lutzii using a zebrafish model. Materials & methods: Preparation and physical-chemical characterization of nanoemulsion (NLS) and NLS + 2'chalc were performed. MIC and minimum fungicide concentration, cytotoxicity and toxicity were also evaluated in the Danio rerio model. Results: NLS + 2'chalc showed fungicidal activity against Paracoccidioides spp. without cytotoxicity in MRC5 and HepG2 lines. It also had high selectivity index values and no toxicity in the zebrafish model based on MIC values. Conclusion: NLS + 2'chalc is a potential new alternative treatment for paracoccidioidomycosis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Paracoccidioides / Chalcones / Antifungal Agents Limits: Animals / Humans Language: En Journal: Future Microbiol Journal subject: MICROBIOLOGIA Year: 2020 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Paracoccidioides / Chalcones / Antifungal Agents Limits: Animals / Humans Language: En Journal: Future Microbiol Journal subject: MICROBIOLOGIA Year: 2020 Document type: Article Affiliation country: Country of publication: