Chia oil induces browning of white adipose tissue in high-fat diet-induced obese mice.
Mol Cell Endocrinol
; 507: 110772, 2020 05 01.
Article
in En
| MEDLINE
| ID: mdl-32114022
ABSTRACT
Previous research suggests that omega-3 fatty acids from animal origin may promote the browning of subcutaneous white adipose tissue. We evaluated if supplementation with a plant oil (chia, Salvia hispanica L.) rich in alpha-linolenic fatty acid (C183; ω-3) would promote browning and improve glucose metabolism in animals subjected to an obesogenic diet. Swiss male mice (n = 28) were divided into 4 groups C control diet; H high-fat diet; HC animals in the H group supplemented with chia oil after reaching obesity; HCW animals fed since weaning on a high-fat diet supplemented with chia oil. Glucose tolerance, inflammatory markers, and expression of genes and proteins involved in the browning process were examined. When supplemented since weaning, chia oil improved glucose metabolism and promoted the browning process and a healthier phenotype. Results of this study suggested that chia oil has potential to protect against the development of obesity-related diseases.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plant Oils
/
Salvia
/
Adipose Tissue, White
/
Cell Transdifferentiation
/
Diet, High-Fat
/
Obesity
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
Mol Cell Endocrinol
Year:
2020
Document type:
Article
Affiliation country: