Standardization of acquisition protocols using PET/CT with 18F-Choline in prostate cancer. / Estandarización de los protocolos de adquisición mediante PET/TC con 18F-Colina en el cáncer de próstata.
Rev Esp Med Nucl Imagen Mol (Engl Ed)
; 39(4): 204-211, 2020.
Article
in En, Es
| MEDLINE
| ID: mdl-32192907
ABSTRACT
AIM:
To standardize acquisition protocols for 18F-Choline PET/CT to prevent from urine interference, to determine the best time point for the whole-body study, and to assess whether "dual point" acquisition allows for differentiating malignant vs. benign lesions.METHODS:
One hundred consecutive patients with prostate cancer were prospectively studied. Immediately after 18F-Choline injection, a pelvis study was acquired, and a whole-body was subsequently obtained 1 and 2 hours p.i. Mean SUVmax was obtained in regions and for every sequential imaging. Mean analysis (χ2) and SUV percentage change (2/1 hours; 1 hours/0 min) were obtained. Metabolic pattern dynamics were assessed accumulative vs. clearance. Patient follow-up after therapy and directed classification whenever ethically possible were performed.RESULTS:
Fifty-three prostate foci, without disturbing urinary activity was ever found on early images. Accumulative pattern in 42, with percentage increase was 0 min/1 hour +16.7% (χ20.94); 1/2 hours +10,0% (χ2 0.83). Clearance pattern in 11, with percentage decrease 0 min/1 hour -21.4% (χ20.91) -7.7% (χ20.85), corresponding in 7 to initial staging and in 4 post-radiotherapy biochemical recurrence. Every infradiaphragmatic uptake (n 24) showed accumulative pattern, with percentage increase of +9.1% (χ20.97), all of them depicted on early imaging. As for 12 supradiaphragmantic uptake, 8 of them showed clearance pattern with percentage decrease -13.0% (χ20.95). Accumulative pattern showed in 4 of them with percentage increase +13.0% (χ2 0.96), thus being assessed as invasive/malignant. Every bone uptake (n 18) showed accumulative pattern, with percentage increase +17.1% (χ20.95), all of them depicted on 1 hour imaging.CONCLUSIONS:
As for prostate assessment is concerned, dual point at 0 min/1 hour proved to be the best procedure. As for supradiaphragmatic lymph-nodes detection, dual point with 1/2 hours performed best. As for infradiaphragmatic and bone involvement, as well as for inconclusive findings, the 2 hour imaging increased our diagnostic confidence.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostatic Neoplasms
/
Fluorine Radioisotopes
/
Adenocarcinoma
/
Choline
/
Radiopharmaceuticals
/
Positron Emission Tomography Computed Tomography
Type of study:
Diagnostic_studies
/
Guideline
/
Observational_studies
Aspects:
Ethics
Limits:
Aged
/
Aged80
/
Humans
/
Male
/
Middle aged
Language:
En
/
Es
Journal:
Rev Esp Med Nucl Imagen Mol (Engl Ed)
Year:
2020
Document type:
Article