Disease severity of respiratory syncytial virus (RSV) infection correlate to a novel set of five amino acid substitutions in the RSV attachment glycoprotein (G) in China.
Virus Res
; 281: 197937, 2020 05.
Article
in En
| MEDLINE
| ID: mdl-32194139
Human respiratory syncytial virus (RSV) is one of the major viruses of acute respiratory tract disease among infants and young children. We performed molecular epidemiology analysis of RSV among inpatient children in Guangzhou, China. Phylogenetic and Bayesian analysis showed that genotype ON1 was the only subgroup A virus in this study. Interestingly, the majority of Guangzhou ON1 strains formed a well-supported cluster, and these strains shared a novel set of five amino acid substitutions that never illustrated before. Furthermore, the degree of disease severity was assessed using a severity scoring system. The patients carrying the novel RSV A strain were associated with milder respiratory symptoms compared to other RSV A positives. In conclusion, a specific set of five amino acid substitutions was found in China and further analysis showed that disease severity was associated with these alterations. These findings will provide valuable information for the pathogenic mechanism and vaccine development of RSV.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Viral Fusion Proteins
/
Respiratory Syncytial Virus, Human
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Respiratory Syncytial Virus Infections
Limits:
Child, preschool
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Female
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Humans
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Infant
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Male
/
Newborn
Country/Region as subject:
Asia
Language:
En
Journal:
Virus Res
Journal subject:
VIROLOGIA
Year:
2020
Document type:
Article
Affiliation country:
Country of publication: