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Longitudinal association of type 2 diabetes and insulin therapy with muscle parameters in the KORA-Age study.
Ferrari, Uta; Then, Cornelia; Rottenkolber, Marietta; Selte, Canan; Seissler, Jochen; Conzade, Romy; Linkohr, Birgit; Peters, Annette; Drey, Michael; Thorand, Barbara.
Affiliation
  • Ferrari U; Geriatrie, Department of Medicine IV, University Hospital, LMU Munich, Ziemssenstraße 1, 80336, Munich, Germany. uta.ferrari@med.uni-muenchen.de.
  • Then C; Geriatrie, Department of Medicine IV, University Hospital, LMU Munich, Ziemssenstraße 1, 80336, Munich, Germany.
  • Rottenkolber M; Geriatrie, Department of Medicine IV, University Hospital, LMU Munich, Ziemssenstraße 1, 80336, Munich, Germany.
  • Selte C; Geriatrie, Department of Medicine IV, University Hospital, LMU Munich, Ziemssenstraße 1, 80336, Munich, Germany.
  • Seissler J; Geriatrie, Department of Medicine IV, University Hospital, LMU Munich, Ziemssenstraße 1, 80336, Munich, Germany.
  • Conzade R; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
  • Linkohr B; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
  • Peters A; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
  • Drey M; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.
  • Thorand B; Geriatrie, Department of Medicine IV, University Hospital, LMU Munich, Ziemssenstraße 1, 80336, Munich, Germany.
Acta Diabetol ; 57(9): 1057-1063, 2020 Sep.
Article in En | MEDLINE | ID: mdl-32246270
AIMS: The aim of the current study was to investigate the association of type 2 diabetes (T2D) and insulin treatment with changes in muscle mass, muscle strength, and physical performance in older adults. METHODS: In 731 participants of the population-based KORA-Age study aged 74.6 ± 6.2 years (T2D: n = 118; insulin treatment: n = 20), skeletal muscle index (SMI [kg/m2]), hand grip strength (GS [kg]), and a timed up and go test (TUG [s]) were performed at baseline and after a follow-up time of 3 years. The association of T2D and insulin therapy with changes in muscle parameters was analyzed using linear regression models. RESULTS: After adjustment for sex, age, BMI, physical activity, smoking, and multimorbidity, T2D was associated with the change in SMI during follow-up (ß - 0.1 (95% CI - 0.3 to - 0.02) kg/m2; p = 0.02), but not with a change in GS (ß - 0.9 (95% CI - 1.9 to 0.04) kg) or TUG (ß - 0.1 (95% CI - 0.7 to 0.5) s). Insulin therapy was positively associated with change in SMI (ß 0.6 (95% CI 0.3-0.9) kg/m2; p = 0.001), but not in GS (ß - 1.6 (95% CI - 4.1 to 0.8) kg) or TUG (ß 1.6 (95% CI - 0.2-3.4) s) in comparison with treatment with oral anti-diabetic medication alone. CONCLUSIONS: Participants with T2D showed an accelerated decline in muscle mass compared to non-diabetic participants. Insulin therapy was associated with preserved muscle mass, but not muscle function parameters, indicating a discrepancy between muscle mass and function in this high-risk population.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscle, Skeletal / Diabetes Mellitus, Type 2 / Muscle Strength / Insulin Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Aged80 / Female / Humans / Male Country/Region as subject: Europa Language: En Journal: Acta Diabetol Journal subject: ENDOCRINOLOGIA Year: 2020 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscle, Skeletal / Diabetes Mellitus, Type 2 / Muscle Strength / Insulin Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Aged80 / Female / Humans / Male Country/Region as subject: Europa Language: En Journal: Acta Diabetol Journal subject: ENDOCRINOLOGIA Year: 2020 Document type: Article Affiliation country: Country of publication: