Postingestive Modulation of Food Seeking Depends on Vagus-Mediated Dopamine Neuron Activity.
Neuron
; 106(5): 778-788.e6, 2020 06 03.
Article
in En
| MEDLINE
| ID: mdl-32259476
ABSTRACT
Postingestive nutrient sensing can induce food preferences. However, much less is known about the ability of postingestive signals to modulate food-seeking behaviors. Here we report a causal connection between postingestive sucrose sensing and vagus-mediated dopamine neuron activity in the ventral tegmental area (VTA), supporting food seeking. The activity of VTA dopamine neurons increases significantly after administration of intragastric sucrose, and deletion of the NMDA receptor in these neurons, which affects bursting and plasticity, abolishes lever pressing for postingestive sucrose delivery. Furthermore, lesions of the hepatic branch of the vagus nerve significantly impair postingestive-dependent VTA dopamine neuron activity and food seeking, whereas optogenetic stimulation of left vagus nerve neurons significantly increases VTA dopamine neuron activity. These data establish a necessary role of vagus-mediated dopamine neuron activity in postingestive-dependent food seeking, which is independent of taste signaling.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Appetitive Behavior
/
Sucrose
/
Vagus Nerve
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Ventral Tegmental Area
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Dopaminergic Neurons
/
Nutritive Sweeteners
Limits:
Animals
Language:
En
Journal:
Neuron
Journal subject:
NEUROLOGIA
Year:
2020
Document type:
Article
Affiliation country: