Diblock- and triblock-copolymer based mixed micelles with high tumor penetration in vitro and in vivo.
J Mater Chem B
; 4(19): 3216-3224, 2016 May 21.
Article
in En
| MEDLINE
| ID: mdl-32263257
ABSTRACT
A series of self-assembled mixed micelles composed of TPGS and Pluronics were fabricated and their cellular uptake and exocytosis behaviors were studied in 2D cell and 3D tumor spheroid models. Together with in vivo efficacy studies, our results demonstrate that TPGS is not only critical to stabilize the mixed micelle structure but also to improve drug loading and facilitate cell penetration and accumulation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Mater Chem B
Year:
2016
Document type:
Article
Affiliation country: