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Optimization of Hydantoins as Potent Antimycobacterial Decaprenylphosphoryl-ß-d-Ribose Oxidase (DprE1) Inhibitors.
Balabon, Olga; Pitta, Eleni; Rogacki, Maciej K; Meiler, Eugenia; Casanueva, Ruth; Guijarro, Laura; Huss, Sophie; Lopez-Roman, Eva Maria; Santos-Villarejo, Ángel; Augustyns, Koen; Ballell, Lluis; Aguirre, David Barros; Bates, Robert H; Cunningham, Fraser; Cacho, Monica; Van der Veken, Pieter.
Affiliation
  • Balabon O; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universitieitsplein 1, 2610 Wilrijk, Belgium.
  • Pitta E; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Rogacki MK; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universitieitsplein 1, 2610 Wilrijk, Belgium.
  • Meiler E; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Casanueva R; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universitieitsplein 1, 2610 Wilrijk, Belgium.
  • Guijarro L; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Huss S; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Lopez-Roman EM; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Santos-Villarejo Á; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Augustyns K; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Ballell L; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Aguirre DB; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Bates RH; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universitieitsplein 1, 2610 Wilrijk, Belgium.
  • Cunningham F; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Cacho M; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Van der Veken P; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
J Med Chem ; 63(10): 5367-5386, 2020 05 28.
Article in En | MEDLINE | ID: mdl-32342688
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Alcohol Oxidoreductases / Hydantoins / Antitubercular Agents Limits: Animals / Female / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Alcohol Oxidoreductases / Hydantoins / Antitubercular Agents Limits: Animals / Female / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: Country of publication: