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Profiling structural diversity and activity of 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia.
Szamosvári, Dávid; Prothiwa, Michaela; Dieterich, Cora Lisbeth; Böttcher, Thomas.
Affiliation
  • Szamosvári D; Department of Chemistry, Konstanz Research School Chemical Biology, Zukunftskolleg, University of Konstanz, 78457 Konstanz, Germany. Thomas.Boettcher@uni-konstanz.de.
  • Prothiwa M; Department of Chemistry, Konstanz Research School Chemical Biology, Zukunftskolleg, University of Konstanz, 78457 Konstanz, Germany. Thomas.Boettcher@uni-konstanz.de.
  • Dieterich CL; Department of Chemistry, Konstanz Research School Chemical Biology, Zukunftskolleg, University of Konstanz, 78457 Konstanz, Germany. Thomas.Boettcher@uni-konstanz.de.
  • Böttcher T; Department of Chemistry, Konstanz Research School Chemical Biology, Zukunftskolleg, University of Konstanz, 78457 Konstanz, Germany. Thomas.Boettcher@uni-konstanz.de and Faculty of Chemistry and Department of Microbiology and Ecosystem Science, University of Vienna, 1090 Vienna, Austria. Thomas.Boet
Chem Commun (Camb) ; 56(47): 6328-6331, 2020 Jun 11.
Article in En | MEDLINE | ID: mdl-32436549
We synthesized all major saturated and unsaturated 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia, quantified their native production levels and characterized their antibiotic activities against competing Staphylococcus aureus. We demonstrate that quinolone core methylation and position of unsaturation in the alkyl-chain dictate antibiotic potency which supports the proposed mechanism of action.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxides / Pseudomonas / Quinolones / Burkholderia / Anti-Bacterial Agents Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxides / Pseudomonas / Quinolones / Burkholderia / Anti-Bacterial Agents Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: Country of publication: