Ellagitannins and simple phenolics from the halophytic plant Tamarix nilotica.
Nat Prod Res
; 36(1): 177-185, 2022 Jan.
Article
in En
| MEDLINE
| ID: mdl-32496129
ABSTRACT
Three new [nilotinins M8âM10 (1â3)] and two known [tamarixinin A (4) and gemin D (5)] ellagitannins and seven simple phenolics [gallic acid (6), methyl gallate (7), 3,4-di-O-methylgallic acid (8), ellagic acid (9), 3-O-methylellagic acid (10), methyl ferulate 3-O-sulphate (11), and 7,4'-di-O-methylkaempferol (12)] were isolated from the halophytic plant Tamarix nilotica (Ehrenb.) Bunge (Tamaricaceae). Their structures were determined based on intensive spectroscopic studies and comparisons with reported data. Compounds 4, and 6-8 were evaluated for their cytotoxicity against lung adenocarcinoma cell line (A549) and anti-leishmanial activity against Leishmania major. Compounds 4, 6 and 7 showed promising cytotoxic properties against A549 (IC50 29 ± 2.3, 10.5 ± 0.7, and 20.7 ± 1.9 µg/mL), while compounds 4 and 7 showed higher growth-inhibitory effects against L. major promastigotes (IC50 40.5 ± 2.7 and 38.4 ± 2.5 µg/mL), as compared with the standards doxorubicin (IC50 0.42 µg/mL) and miltefosine (IC50 9.43 µg/mL), respectively.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tamaricaceae
/
Hydrolyzable Tannins
/
Antineoplastic Agents, Phytogenic
/
Antiprotozoal Agents
Limits:
Humans
Language:
En
Journal:
Nat Prod Res
Year:
2022
Document type:
Article
Affiliation country: