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Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(ii) superoxide dismutase mimic complex.
Mathieu, Emilie; Bernard, Anne-Sophie; Quévrain, Elodie; Zoumpoulaki, Martha; Iriart, Sébastien; Lung-Soong, Caroline; Lai, Barry; Medjoubi, Kadda; Henry, Lucas; Nagarajan, Sounderya; Poyer, Florent; Scheitler, Andreas; Ivanovic-Burmazovic, Ivana; Marco, Sergio; Somogyi, Andrea; Seksik, Philippe; Delsuc, Nicolas; Policar, Clotilde.
Affiliation
  • Mathieu E; Laboratoire des biomolécules, LBM, Département de chimie, Ecole normale supérieure, PSL University, Sorbonne université, CNRS, 75005 Paris, France. clotilde.policar@ens.fr.
Chem Commun (Camb) ; 56(57): 7885-7888, 2020 Jul 21.
Article in En | MEDLINE | ID: mdl-32520039
ABSTRACT
A conjugate of a Mn-based superoxide dismutase mimic with a Re-based multimodal probe 1[combining low line] was studied in a cellular model of oxidative stress. Its speciation was investigated using Re and Mn X-fluorescence. Interestingly, 1[combining low line] shows a distribution different from its unconjugated analogue but a similar concentration in mitochondria and a similar bioactivity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rhenium / Superoxide Dismutase / Anti-Inflammatory Agents, Non-Steroidal / Coordination Complexes Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rhenium / Superoxide Dismutase / Anti-Inflammatory Agents, Non-Steroidal / Coordination Complexes Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: