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Pharmacokinetic and pharmacodynamic modeling of the metastin/kisspeptin analog, TAK-448, for its anti-tumor efficacy in a rat xenograft model.
Kogame, Akifumi; Ishikawa, Kaori; DeJongh, Joost; Tagawa, Yoshihiko; Matsui, Hisanori; Moriya, Yuu; Kondo, Takahiro; Asahi, Satoru.
Affiliation
  • Kogame A; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
  • Ishikawa K; Oncology Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
  • DeJongh J; Leiden Experts on Advanced Pharmacokinetics & Pharmacodynamics, Leiden, the Netherlands.
  • Tagawa Y; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
  • Matsui H; XVGen Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
  • Moriya Y; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
  • Kondo T; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
  • Asahi S; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan.
Biopharm Drug Dispos ; 41(7): 283-294, 2020 Jul.
Article in En | MEDLINE | ID: mdl-32562504
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Antineoplastic Agents, Hormonal / Kisspeptins / Models, Biological Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Biopharm Drug Dispos Year: 2020 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Antineoplastic Agents, Hormonal / Kisspeptins / Models, Biological Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Biopharm Drug Dispos Year: 2020 Document type: Article Affiliation country: Country of publication: