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An automated and high-throughput-screening compatible pluripotent stem cell-based test platform for developmental and reproductive toxicity assessment of small molecule compounds.
Witt, Gesa; Keminer, Oliver; Leu, Jennifer; Tandon, Rashmi; Meiser, Ina; Willing, Anne; Winschel, Ingo; Abt, Jana-Christin; Brändl, Björn; Sébastien, Isabelle; Friese, Manuel A; Müller, Franz-Josef; Neubauer, Julia C; Claussen, Carsten; Zimmermann, Heiko; Gribbon, Philip; Pless, Ole.
Affiliation
  • Witt G; Fraunhofer IME ScreeningPort, Schnackenburgallee 114, 22525, Hamburg, Germany.
  • Keminer O; Fraunhofer IME ScreeningPort, Schnackenburgallee 114, 22525, Hamburg, Germany.
  • Leu J; Fraunhofer IME ScreeningPort, Schnackenburgallee 114, 22525, Hamburg, Germany.
  • Tandon R; Fraunhofer IME ScreeningPort, Schnackenburgallee 114, 22525, Hamburg, Germany.
  • Meiser I; Fraunhofer IBMT, 66280, Sulzbach, Saar, Germany.
  • Willing A; Institut für Neuroimmunologie und Multiple Sklerose, Zentrum für Molekulare Neurobiologie Hamburg, Universitätsklinikum Hamburg-Eppendorf, 20251, Hamburg, Germany.
  • Winschel I; Institut für Neuroimmunologie und Multiple Sklerose, Zentrum für Molekulare Neurobiologie Hamburg, Universitätsklinikum Hamburg-Eppendorf, 20251, Hamburg, Germany.
  • Abt JC; Fraunhofer IME ScreeningPort, Schnackenburgallee 114, 22525, Hamburg, Germany.
  • Brändl B; Christian-Albrechts-Universität zu Kiel, ZIP gGmbH, 24105, Kiel, Germany.
  • Sébastien I; Fraunhofer IBMT, 66280, Sulzbach, Saar, Germany.
  • Friese MA; Institut für Neuroimmunologie und Multiple Sklerose, Zentrum für Molekulare Neurobiologie Hamburg, Universitätsklinikum Hamburg-Eppendorf, 20251, Hamburg, Germany.
  • Müller FJ; Christian-Albrechts-Universität zu Kiel, ZIP gGmbH, 24105, Kiel, Germany.
  • Neubauer JC; Fraunhofer IBMT, 66280, Sulzbach, Saar, Germany.
  • Claussen C; Fraunhofer IME ScreeningPort, Schnackenburgallee 114, 22525, Hamburg, Germany.
  • Zimmermann H; Fraunhofer IBMT, 66280, Sulzbach, Saar, Germany.
  • Gribbon P; Lehrstuhl für Molekulare und Zelluläre Biotechnologie, Universität des Saarlandes, 66123, Saarbrücken, Germany.
  • Pless O; Fakultät für Meereswissenschaften, Universidad Católica del Norte, CL-1781421, Coquimbo, Chile.
Cell Biol Toxicol ; 37(2): 229-243, 2021 04.
Article in En | MEDLINE | ID: mdl-32564278
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reproduction / Toxicity Tests / Pluripotent Stem Cells / Embryonic Development / Small Molecule Libraries / High-Throughput Screening Assays Type of study: Diagnostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: Cell Biol Toxicol Journal subject: TOXICOLOGIA Year: 2021 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reproduction / Toxicity Tests / Pluripotent Stem Cells / Embryonic Development / Small Molecule Libraries / High-Throughput Screening Assays Type of study: Diagnostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: Cell Biol Toxicol Journal subject: TOXICOLOGIA Year: 2021 Document type: Article Affiliation country: Country of publication: