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A natural BACE1 and GSK3ß dual inhibitor Notopterol effectively ameliorates the cognitive deficits in APP/PS1 Alzheimer's mice by attenuating amyloid-ß and tau pathology.
Jiang, Xiaowen; Lu, Hongyuan; Li, Jingda; Liu, Wenwu; Wu, Qiong; Xu, Zihua; Qiao, Qinglong; Zhang, Haotian; Gao, Huiyuan; Zhao, Qingchun.
Affiliation
  • Jiang X; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
  • Lu H; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, People's Republic of China.
  • Li J; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
  • Liu W; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
  • Wu Q; School of Life Sciences, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
  • Xu Z; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
  • Qiao Q; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, People's Republic of China.
  • Zhang H; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
  • Gao H; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
  • Zhao Q; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, People's Republic of China.
Clin Transl Med ; 10(3): e50, 2020 Jul.
Article in En | MEDLINE | ID: mdl-32652879
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Clin Transl Med Year: 2020 Document type: Article
Fulltext
Add to My VHL
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XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Clin Transl Med Year: 2020 Document type: Article