Dichloroacetate reveals the presence of metabolic inertia at the start of exercise in rainbow trout (Oncorhynchus mykiss, Walbaum 1792).
J Fish Biol
; 97(4): 1242-1246, 2020 Oct.
Article
in En
| MEDLINE
| ID: mdl-32657450
ABSTRACT
A lag in the increase in oxygen consumption (MO2 ) occurs at the start of sustainable exercise in trout. Waterborne dichloroacetate (0.58 and 3.49 mmol l-1 ), a compound which activates pyruvate dehydrogenase (PDH) by inhibiting PDH kinase in muscle, accelerates the increase in MO2 during the first 10 min of sustainable exercise when velocity is elevated to 75% critical swimming speed in a swim tunnel. There are no effects on MO2 thereafter or at rest. This indicates that a delay in PDH activation ("metabolic inertia") contributes to the lag phenomenon.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxygen Consumption
/
Swimming
/
Oncorhynchus mykiss
/
Dichloroacetic Acid
/
Energy Metabolism
Limits:
Animals
Language:
En
Journal:
J Fish Biol
Year:
2020
Document type:
Article
Affiliation country: