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Metformin inhibits RAN translation through PKR pathway and mitigates disease in C9orf72 ALS/FTD mice.
Zu, Tao; Guo, Shu; Bardhi, Olgert; Ryskamp, Daniel A; Li, Jian; Khoramian Tusi, Solaleh; Engelbrecht, Avery; Klippel, Kelena; Chakrabarty, Paramita; Nguyen, Lien; Golde, Todd E; Sonenberg, Nahum; Ranum, Laura P W.
Affiliation
  • Zu T; Center for NeuroGenetics, College of Medicine, University of Florida, Gainesville, FL 32610.
  • Guo S; Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL 32610.
  • Bardhi O; Genetics Institute, University of Florida, Gainesville, FL 32610.
  • Ryskamp DA; Center for NeuroGenetics, College of Medicine, University of Florida, Gainesville, FL 32610.
  • Li J; Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL 32610.
  • Khoramian Tusi S; Genetics Institute, University of Florida, Gainesville, FL 32610.
  • Engelbrecht A; Center for NeuroGenetics, College of Medicine, University of Florida, Gainesville, FL 32610.
  • Klippel K; Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL 32610.
  • Chakrabarty P; Genetics Institute, University of Florida, Gainesville, FL 32610.
  • Nguyen L; Center for NeuroGenetics, College of Medicine, University of Florida, Gainesville, FL 32610.
  • Golde TE; Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL 32610.
  • Sonenberg N; Genetics Institute, University of Florida, Gainesville, FL 32610.
  • Ranum LPW; Center for NeuroGenetics, College of Medicine, University of Florida, Gainesville, FL 32610.
Proc Natl Acad Sci U S A ; 117(31): 18591-18599, 2020 08 04.
Article in En | MEDLINE | ID: mdl-32690681
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Biosynthesis / EIF-2 Kinase / C9orf72 Protein / Amyotrophic Lateral Sclerosis / Metformin Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Biosynthesis / EIF-2 Kinase / C9orf72 Protein / Amyotrophic Lateral Sclerosis / Metformin Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Document type: Article